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Understanding rare and common diseases in the context of human evolutionFire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern HumansGenetics of Type 2 Diabetes: the Power of Isolated Populations.The role of functional data in interpreting the effects of genetic variationA flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets.Rare variants of small effect size in neuronal excitability genes influence clinical outcome in Japanese cases of SCN1A truncation-positive Dravet syndrome.Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.The effects of sample size on population genomic analyses--implications for the tests of neutrality.The Genetic Cost of Neanderthal Introgression.A new conceptual framework for investigating complex genetic disease.Worldwide Increase of Obesity Is Related to the Reduced Opportunity for Natural Selection.Exomic variants of an elderly cohort of Brazilians in the ABraOM database.Patterns of deleterious variation between human populations reveal an unbalanced load.Distance from sub-Saharan Africa predicts mutational load in diverse human genomes.Association-heterogeneity mapping identifies an Asian-specific association of the GTF2I locus with rheumatoid arthritis.The Qatar genome: a population-specific tool for precision medicine in the Middle EastSemiparametric Allelic Tests for Mapping Multiple Phenotypes: Binomial Regression and Mahalanobis Distance.The Role of Deleterious Substitutions in Crop Genomes.Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry.Multiple rare genetic variants co-segregating with familial IgA nephropathy all act within a single immune-related network.The evolution of the human genome.A genomic perspective on HLA evolution.Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?Living in an adaptive world: Genomic dissection of the genus Homo and its immune response.Carrier Screening is a Deficient Strategy for Determining Sperm Donor Eligibility and Reducing Risk of Disease in Recipient Children.Genetic Diversity and the Efficacy of Purifying Selection across Plant and Animal Species.The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.Quantifying unobserved protein-coding variants in human populations provides a roadmap for large-scale sequencing projects.Genome-Wide Association Studies of Chemotherapeutic Toxicities: Genomics of Inequality.From Peas to Disease: Modifier Genes, Network Resilience, and the Genetics of Health.Recombination Rate Variation, Hitchhiking, and Demographic History Shape Deleterious Load in Poplar.PReFerSim: fast simulation of demography and selection under the Poisson Random Field model.When Is Selection Effective?Accumulation of Deleterious Mutations During Bacterial Range Expansions.MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population.The interplay of demography and selection during maize domestication and expansion.Genetic costs of domestication and improvement.Fine-scale genetic structure due to adaptive divergence among microhabitats.The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 May 2015
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Estimating the mutation load in human genomes
@en
Estimating the mutation load in human genomes.
@nl
type
label
Estimating the mutation load in human genomes
@en
Estimating the mutation load in human genomes.
@nl
prefLabel
Estimating the mutation load in human genomes
@en
Estimating the mutation load in human genomes.
@nl
P2860
P50
P356
P1476
Estimating the mutation load in human genomes
@en
P2093
Andrew G Clark
Simon Gravel
P2860
P2888
P304
P356
10.1038/NRG3931
P577
2015-05-12T00:00:00Z