Quality control of a transcriptional regulator by SUMO-targeted degradation
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Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradationFunction and regulation of SUMO proteasesProtein quality control in the nucleusCentromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligasesRING domain dimerization is essential for RNF4 functionThe SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.SUMO-Targeted Ubiquitin Ligase (STUbL) Slx5 regulates proteolysis of centromeric histone H3 variant Cse4 and prevents its mislocalization to euchromatin.Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic StressDegradation of the Saccharomyces cerevisiae mating-type regulator alpha1: genetic dissection of cis-determinants and trans-acting pathwaysGenetic analysis implicates the Set3/Hos2 histone deacetylase in the deposition and remodeling of nucleosomes containing H2A.Z.SUMO functions in constitutive transcription and during activation of inducible genes in yeast.How the nucleus copes with proteotoxic stress.Genetic evidence that polysumoylation bypasses the need for a SUMO-targeted Ub ligase.The fate of metaphase kinetochores is weighed in the balance of SUMOylation during S phase.Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression.Exposed hydrophobicity is a key determinant of nuclear quality control degradation.A cellular system that degrades misfolded proteins and protects against neurodegenerationThe Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax.Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.STUbLs in chromatin and genome stability.Substrate recognition in nuclear protein quality control degradation is governed by exposed hydrophobicity that correlates with aggregation and insolubility.Means of self-preservation: how an intrinsically disordered ubiquitin-protein ligase averts self-destruction.Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.Physical and Genetic Interactions Between Uls1 and the Slx5-Slx8 SUMO-Targeted Ubiquitin Ligase.Role of RNF4 in the ubiquitination of Rta of Epstein-Barr virus.A SUMO-targeted ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3 ligase Siz1.Starting and stopping SUMOylation. What regulates the regulator?Protein quality control in the nucleus.Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic ProgressionA Lysine Desert Protects a Novel Domain in the Slx5-Slx8 SUMO Targeted Ub Ligase To Maintain Sumoylation Levels in Saccharomyces cerevisiae.SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor.A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA.Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligase.Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity.Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins.Multiple crosstalks between mRNA biogenesis and SUMO.SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of HuntingtinDefective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway
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Quality control of a transcriptional regulator by SUMO-targeted degradation
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 12 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Quality control of a transcriptional regulator by SUMO-targeted degradation
@en
Quality control of a transcriptional regulator by SUMO-targeted degradation.
@nl
type
label
Quality control of a transcriptional regulator by SUMO-targeted degradation
@en
Quality control of a transcriptional regulator by SUMO-targeted degradation.
@nl
prefLabel
Quality control of a transcriptional regulator by SUMO-targeted degradation
@en
Quality control of a transcriptional regulator by SUMO-targeted degradation.
@nl
P2860
P356
P1476
Quality control of a transcriptional regulator by SUMO-targeted degradation
@en
P2093
Gregory Prelich
Zheng Wang
P2860
P304
P356
10.1128/MCB.01470-08
P407
P577
2009-01-12T00:00:00Z