DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia - Test2 - elhamkhani - TriplyDB

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

http://www.wikidata.org/entity/Q37130889

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Personalized therapy tests for the monitoring of chronic lymphocytic leukemia development.Intratumoral Heterogeneity of the Epigenome.Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease Epigenetic silencing of miR-26A1 in chronic lymphocytic leukemia and mantle cell lymphoma: Impact on EZH2 expression High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells Global DNA methylation profiling reveals new insights into epigenetically deregulated protein coding and long noncoding RNAs in CLL.Evaluation of Methylation Biomarkers for Detection of Circulating Tumor DNA and Application to Colorectal Cancer Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.Chronic lymphocytic leukemia: Time to go past genomics?Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage.Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups.Clinical Implications of Novel Genomic Discoveries in Chronic Lymphocytic Leukemia.DNA methylation-based variation between human populations.Targeting the cancer epigenome for therapy.Human memory B cells.DNA methylation profiling reveals the presence of population-specific signatures correlating with phenotypic characteristics.Coevolution of Leukemia and Host Immune Cells in Chronic Lymphocytic Leukemia.IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus.Epigenetic modification of nucleic acids: from basic studies to medical applications.Chronic lymphocytic leukaemia genomics and the precision medicine era.Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas.Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis.Targeting methionine cycle as a potential therapeutic strategy for immune disorders.Higher Nevus Count Exhibits a Distinct DNA Methylation Signature in Healthy Human Skin: Implications for Melanoma.EGR2 mutations define a new clinically aggressive subgroup of chronic lymphocytic leukemia.A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis.The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling.Alterations in DNA methylation/demethylation intermediates predict clinical outcome in chronic lymphocytic leukemia Dissection of CD20 regulation in lymphoma using RNAi.Chromatin marks shape mutation landscape at early stage of cancer progression.RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.Drug-perturbation-based stratification of blood cancer.150 years of Johann Gregor Mendel's "Versuche über Pflanzen-Hybriden".NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib.The expression of hematopoietic progenitor cell antigen CD34 is regulated by DNA methylation in a site-dependent manner in gastrointestinal stromal tumours.Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin.Clonal evolution in leukemia.Proteomics profiling of CLL versus healthy B-cells identifies putative therapeutic targets and a subtype-independent signature of spliceosome dysregulation.Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations.SnapShot: Chronic Lymphocytic Leukemia.

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DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

http://www.wikidata.org/entity/Q37130889

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 18 January 2016

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

DNA methylation dynamics durin ...... n chronic lymphocytic leukemia

@en

DNA methylation dynamics durin ...... chronic lymphocytic leukemia.

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type

label

DNA methylation dynamics durin ...... n chronic lymphocytic leukemia

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DNA methylation dynamics durin ...... chronic lymphocytic leukemia.

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prefLabel

DNA methylation dynamics durin ...... n chronic lymphocytic leukemia

@en

DNA methylation dynamics durin ...... chronic lymphocytic leukemia.

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Nature Genetics

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DNA methylation dynamics durin ...... n chronic lymphocytic leukemia

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Amy S Ruppert

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Andrius Serva

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Charles D Imbusch

http://www.w3.org/2001/XMLSchema#string

Christoph Plass

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Christopher C Oakes

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Daniel B Lipka

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David Brocks

http://www.w3.org/2001/XMLSchema#string

Dieter Weichenhan

http://www.w3.org/2001/XMLSchema#string

Laura Rassenti

http://www.w3.org/2001/XMLSchema#string

Lei Gu

http://www.w3.org/2001/XMLSchema#string

P2860

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Epigenomics of leukemia: from mechanisms to therapeutic applications

The helix-loop-helix gene E2A is required for B cell formation

Fast and accurate long-read alignment with Burrows-Wheeler transform

The ENCODE (ENCyclopedia Of DNA Elements) Project

Mapping and analysis of chromatin state dynamics in nine human cell types

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

GREAT improves functional interpretation of cis-regulatory regions

Integrative analysis of 111 reference human epigenomes

DNA methylation: roles in mammalian development

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253-264

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scholarly article

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10.1038/NG.3488

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3

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Stephan Stilgenbauer

Martina Przekopowitz

Hartmut Döhner

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2016-01-18T00:00:00Z

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26780610

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DNA methylation

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4963005

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