Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola.
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Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic ApproachesComplement and dysbiosis in periodontal diseaseStructure of Factor H-binding Protein B (FhbB) of the Periopathogen,Treponema denticolaGenetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis.Factor H Family Proteins in Complement Evasion of Microorganisms.Virulence factors of the oral spirochete Treponema denticola.Treponema denticola PrcB is required for expression and activity of the PrcA-PrtP (dentilisin) complex.The Borrelia hermsii factor H binding protein FhbA is not required for infectivity in mice or for resistance to human complement in vitro.Complement control protein factor H: the good, the bad, and the inadequate.Treponema denticola chymotrypsin-like proteinase (CTLP) integrates spirochaetes within oral microbial communitiesAnalysis of the complement sensitivity of oral treponemes and the potential influence of FH binding, FH cleavage and dentilisin activity on the pathogenesis of periodontal disease.Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia.The Treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2-dependent fibronectin fragmentation in periodontal ligament cellsIdentification of the primary mechanism of complement evasion by the periodontal pathogen, Treponema denticola.Role of complement in host-microbe homeostasis of the periodontium.Polymicrobial synergy and dysbiosis in inflammatory disease.Dentipain, a Streptococcus pyogenes IdeS protease homolog, is a novel virulence factor of Treponema denticolaComposition and localization of Treponema denticola outer membrane complexes.Treponema denticola interactions with host proteinsConservation and revised annotation of the Treponema denticola prcB-prcA-prtP locus encoding the dentilisin (CTLP) protease complex.The rickettsial OmpB β-peptide of Rickettsia conorii is sufficient to facilitate factor H-mediated serum resistanceProtease-dependent mechanisms of complement evasion by bacterial pathogens.The Treponema denticola FhbB Protein Is a Dominant Early Antigen That Elicits FhbB Variant-Specific Antibodies That Block Factor H Binding and Cleavage by Dentilisin.Sequence divergence in the Treponema denticola FhbB protein and its impact on factor H binding.A surface-exposed neuraminidase affects complement resistance and virulence of the oral spirochaete Treponema denticola.Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host.Complement and periodontitis.The complement system and its role in the pathogenesis of periodontitis: current concepts.The Cross-Talk between Spirochetal Lipoproteins and Immunity.The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H.FACIN, a Double-Edged Sword of the Emerging Periodontal Pathogen Filifactor alocis: A Metabolic Enzyme Moonlighting as a Complement Inhibitor.The Hpk2-Rrp2 two-component regulatory system of Treponema denticola: a potential regulator of environmental and adaptive responses.Crystallization of the factor H-binding protein, FhbB, from the periopathogen Treponema denticolaGene Regulation, Two Component Regulatory Systems, and Adaptive Responses in Treponema Denticola.Treponema denticola increases MMP-2 expression and activation in the periodontium via reversible DNA and histone modifications.Fusobacterium nucleatum binding to complement regulatory protein CD46 modulates the expression and secretion of cytokines and matrix metalloproteinases by oral epithelial cells.
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Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Analysis of a unique interacti ...... pathogen Treponema denticola.
@en
Analysis of a unique interacti ...... pathogen Treponema denticola.
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type
label
Analysis of a unique interacti ...... pathogen Treponema denticola.
@en
Analysis of a unique interacti ...... pathogen Treponema denticola.
@nl
prefLabel
Analysis of a unique interacti ...... pathogen Treponema denticola.
@en
Analysis of a unique interacti ...... pathogen Treponema denticola.
@nl
P2093
P2860
P356
P1476
Analysis of a unique interacti ...... l pathogen Treponema denticola
@en
P2093
Bernice Huang
J Christopher Fenno
John V McDowell
P2860
P304
P356
10.1128/IAI.01544-08
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P577
2009-02-09T00:00:00Z