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Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal modelsTherapeutic and diagnostic challenges for frontotemporal dementiaMaintenance of synaptic stability requires calcium-independent phospholipase A₂ activityNeuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylationAPP processing in Alzheimer's diseaseModeling the complex pathology of Alzheimer's disease in DrosophilaTau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brainAlpha-synuclein and tau: teammates in neurodegeneration?Proteolytic processing of Alzheimer's β-amyloid precursor proteinHDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytesChanges in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau.Proteasome inhibition drives HDAC6-dependent recruitment of tau to aggresomes.Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity.Mass spectrometry identifies multiple organophosphorylated sites on tubulin.Acetylation: a new key to unlock tau's role in neurodegenerationTargeting Abeta and tau in Alzheimer's disease, an early interim reportThe effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease.Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases.Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases.Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutationsPhosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragmentsInfantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: relevance to AD.Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EBBeneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice.Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration.Dysregulation of protein trafficking in neurodegeneration.Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb).Investigating interventions in Alzheimer's disease with computer simulation modelsThe role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathyBimolecular fluorescence complementation; lighting-up tau-tau interaction in living cells.Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathologyTau splicing and the intricacies of dementia.Advances in tau-based drug discovery.The Interface between Cytoskeletal Aberrations and Mitochondrial Dysfunction in Alzheimer's Disease and Related DisordersExpression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption.Aggregation of MBP in chronic demyelination.Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The role of tau in neurodegeneration
@en
The role of tau in neurodegeneration.
@nl
type
label
The role of tau in neurodegeneration
@en
The role of tau in neurodegeneration.
@nl
prefLabel
The role of tau in neurodegeneration
@en
The role of tau in neurodegeneration.
@nl
P2860
P356
P1476
The role of tau in neurodegeneration
@en
P2093
Tania F Gendron
P2860
P2888
P356
10.1186/1750-1326-4-13
P577
2009-03-11T00:00:00Z
P5875
P6179
1009091015