PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. - Test2 - elhamkhani - TriplyDB

PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart.

PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart.

http://www.wikidata.org/entity/Q37189947

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New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond Mitochondria as a therapeutic target in heart failure Heart failure and mitochondrial dysfunction: the role of mitochondrial fission/fusion abnormalities and new therapeutic strategies Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure.A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth The role of PGC-1 coactivators in aging skeletal muscle and heart.Defective DNA replication impairs mitochondrial biogenesis in human failing hearts Dysregulation of cardiolipin biosynthesis in pediatric heart failure.Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice.Increased expression of fatty-acid and calcium metabolism genes in failing human heart.Dynamic gene expression patterns in animal models of early and late heart failure reveal biphasic-bidirectional transcriptional activation of signaling pathways.Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.The PGC-1 cascade as a therapeutic target for heart failure Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases Modulating fatty acid oxidation in heart failure.Glucose metabolism and cardiac hypertrophy Peripartum cardiomyopathy and dilated cardiomyopathy: different at heart.Cardiac function and disease: emerging role of small ubiquitin-related modifier.Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease.Sex differences in cardiomyocyte connexin43 expression.Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction.Mechanical unloading promotes myocardial energy recovery in human heart failure.Cardiomyocyte triglyceride accumulation and reduced ventricular function in mice with obesity reflect increased long chain Fatty Acid uptake and de novo Fatty Acid synthesis.Maintaining ancient organelles: mitochondrial biogenesis and maturation.A murine model of isolated cardiac steatosis leads to cardiomyopathy.Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure.Transcriptional control of cardiac fuel metabolism and mitochondrial function Diastolic Dysfunction Induced by a High-Fat Diet Is Associated with Mitochondrial Abnormality and Adenosine Triphosphate Levels in Rats.Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart.Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.Chronic ethanol consumption increases cardiomyocyte fatty acid uptake and decreases ventricular contractile function in C57BL/6J mice Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study.Increased expression of estrogen-related receptor β during adaptation of adult cardiomyocytes to sustained hypoxia Telomeres and mitochondria in the aging heart.Heme levels are increased in human failing hearts Mitochondria and heart failure: new insights into an energetic problem.Will global transcriptome analysis allow the detection of novel prognostic markers in coronary artery disease and heart failure?Mitochondrial Homeostasis in Acute Organ Failure.

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P2860

PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart.

http://www.wikidata.org/entity/Q37189947

description

2008 nî lūn-bûn

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2008年の論文

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PGC-1alpha and ERRalpha target ...... re of the failing human heart.

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PGC-1alpha and ERRalpha target ...... re of the failing human heart.

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type

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PGC-1alpha and ERRalpha target ...... re of the failing human heart.

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PGC-1alpha and ERRalpha target ...... re of the failing human heart.

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prefLabel

PGC-1alpha and ERRalpha target ...... re of the failing human heart.

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PGC-1alpha and ERRalpha target ...... re of the failing human heart.

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J.YJMCC.2008.10.025

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Journal of Molecular and Cellular Cardiology

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PGC-1alpha and ERRalpha target ...... re of the failing human heart.

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Allie Y Li

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Carmen C Sucharov

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John J Lehman

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Sharon Cresci

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Smita Sihag

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P2860

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation.

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells

Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

Ultrasensitivity in the mitogen-activated protein kinase cascade

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha

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201-212

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