Glycosylation and functionality of recombinant β-glucocerebrosidase from various production systems. - Test2 - elhamkhani - TriplyDB

Glycosylation and functionality of recombinant β-glucocerebrosidase from various production systems.

Glycosylation and functionality of recombinant β-glucocerebrosidase from various production systems.

http://www.wikidata.org/entity/Q37196619

about

Glucocerebrosidase is shaking up the synucleinopathies Large-scale production of pharmaceutical proteins in plant cell culture-the Protalix experience Molecular pharming's foot in the FDA's door: Protalix's trailblazing story Rapid assays for lectin toxicity and binding changes that reflect altered glycosylation in mammalian cells.Direct site-specific glycoform identification and quantitative comparison of glycoprotein therapeutics: imiglucerase and velaglucerase alfa Glycan modulation and sulfoengineering of anti-HIV-1 monoclonal antibody PG9 in plants.Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes.Site-targeted mutagenesis for stabilization of recombinant monoclonal antibody expressed in tobacco (Nicotiana tabacum) plants.Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives.A peptide-linked recombinant glucocerebrosidase for targeted neuronal delivery: Design, production, and assessment.Glyco-engineering strategies for the development of therapeutic enzymes with improved efficacy for the treatment of lysosomal storage diseases.Commercialization of new biotechnology: a systematic review of 16 commercial case studies in a novel manufacturing sector.Using glyco-engineering to produce therapeutic proteins.Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators Plant-based oral delivery of β-glucocerebrosidase as an enzyme replacement therapy for Gaucher's disease.The production of human glucocerebrosidase in glyco-engineered Nicotiana benthamiana plants Reduced paucimannosidic N-glycan formation by suppression of a specific β-hexosaminidase from Nicotiana benthamiana.Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems-The taliglucerase alfa story.Membrane anchors effectively traffic recombinant human glucocerebrosidase to the protein storage vacuole of Arabidopsis seeds but do not adequately control N-glycan maturation.Taliglucerase alfa: safety and efficacy across 6 clinical studies in adults and children with Gaucher disease.Pharmacotherapy of Gaucher Disease: Current and Future Options.

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Glycosylation and functionality of recombinant β-glucocerebrosidase from various production systems.

http://www.wikidata.org/entity/Q37196619

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 25 September 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Glycosylation and functionalit ...... om various production systems.

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Glycosylation and functionalit ...... om various production systems.

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type

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Glycosylation and functionalit ...... om various production systems.

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Glycosylation and functionalit ...... om various production systems.

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Glycosylation and functionalit ...... om various production systems.

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Glycosylation and functionalit ...... om various production systems.

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Bioscience Reports

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Glycosylation and functionalit ...... om various production systems.

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Anna Gantman

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David Aviezer

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Mariana Hainrichson

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Myriam Golembo

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Salit Tzaban

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Tali Kizhner

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Yoram Tekoah

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Yoseph Shaaltiel

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P2860

X-ray structure of human acid-β-glucosidase, the defective enzyme in Gaucher disease

Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease

Characterization of gene-activated human acid- -glucosidase: Crystal structure, glycan composition, and internalization into macrophages

Development of monocytes, macrophages, and dendritic cells

Establishment and characterization of a human histiocytic lymphoma cell line (U-937)

Protective and pathogenic functions of macrophage subsets

Controlled glycosylation of therapeutic antibodies in plants.

Effectiveness of enzyme replacement therapy in 1028 patients with type 1 Gaucher disease after 2 to 5 years of treatment: a report from the Gaucher Registry.

Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening.

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scholarly article

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10.1042/BSR20130081

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5

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33

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2013-09-25T00:00:00Z

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23980545

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3782720

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