Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
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Transient receptor potential (TRP) channels as drug targets for diseases of the digestive systemNitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline)Species-specific temperature sensitivity of TRPA1Redox and trace metal regulation of ion channels in the pain pathwayThe Critical Roles of Zinc: Beyond Impact on Myocardial SignalingPermeation, regulation and control of expression of TRP channels by trace metal ionsA Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applicationsMethylglyoxal evokes pain by stimulating TRPA1Enhanced susceptibility to spontaneous seizures of noda epileptic rats by loss of synaptic zn(2+)Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12)Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation.The Concise Guide to PHARMACOLOGY 2013/14: ion channelsZn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain.Transient increase in Zn2+ in hippocampal CA1 pyramidal neurons causes reversible memory deficit.Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermisZinc: indications in brain disorders.Streptozotocin Stimulates the Ion Channel TRPA1 Directly: INVOLVEMENT OF PEROXYNITRITE1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.Involvement of TRPA1 activation in acute pain induced by cadmium in miceHeavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1.Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity.TRPA1 modulators in preclinical development.Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents.Zinc homeostasis and signaling in health and diseases: Zinc signaling.The transient receptor potential channel TRPA1: from gene to pathophysiology.Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.The Role of Presenilin in Protein Trafficking and Degradation-Implications for Metal Homeostasis.Divalent cations modulate TMEM16A calcium-activated chloride channels by a common mechanism.Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner.Clioquinol induces cytoplasmic clearance of the X-linked inhibitor of apoptosis protein (XIAP): therapeutic indication for prostate cancer.Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins.The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity.Clinical Evaluation of a New-Formula Shampoo for Scalp Seborrheic Dermatitis Containing Extract of Rosa centifolia Petals and Epigallocatechin Gallate: A Randomized, Double-Blind, Controlled Study.Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release.Transient receptor potential A1 channels regulate epithelial cell barriers formed by MDCK cells.2-Amino-4-arylthiazole compounds as TRPA1 antagonists (WO 2012085662): a patent evaluation.TRPA1 channels: molecular sentinels of cellular stress and tissue damage.Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain.Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature.
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P2860
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 05 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
@en
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
@nl
type
label
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
@en
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
@nl
prefLabel
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
@en
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
@nl
P2860
P356
P1476
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
@en
P2093
Clive Gentry
P2860
P304
P356
10.1073/PNAS.0812675106
P407
P577
2009-05-05T00:00:00Z