Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.
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The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human CellsThe role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologiesIn silico model-based inference: a contemporary approach for hypothesis testing in network biologyCilium assembly and disassemblyBifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.An epigenetically distinct breast cancer cell subpopulation promotes collective invasionDiversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous NeoplasmThe transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells.Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.The development of highly potent inhibitors for porcupine.The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer.The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.LKB1 and AMPK differentially regulate pancreatic β-cell identity.Modeling human disease in humans: the ciliopathies.Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readoutsThe Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.Can we safely target the WNT pathway?Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome.Proteomics of Primary Cilia by Proximity LabelingAMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma.Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis.Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation.LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitmentThe E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma.Requirement for stromal estrogen receptor alpha in cervical neoplasiaSecreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex.Gpr161 anchoring of PKA consolidates GPCR and cAMP signalingSystematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancerTargeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms.Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells.LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.The Yes-associated protein controls the cell density regulation of Hedgehog signalingKIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition.Cell biology. The unusual case of Porcupine.DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway.Targeting Class I Histone Deacetylases by the Novel Small Molecule Inhibitor 4SC-202 Blocks Oncogenic Hedgehog-GLI Signaling and Overcomes Smoothened Inhibitor Resistance.Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
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Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 25 January 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.
@en
Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.
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type
label
Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.
@en
Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.
@nl
prefLabel
Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.
@en
Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.
@nl
P2093
P2860
P1433
P1476
Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling
@en
P2093
Baolin Wang
Baozhi Chen
Chih-Wei Fan
James F Amatruda
Lawrence Lum
Leni S Jacob
Michael E Dodge
Ozlem Kulak
Xiaofeng Wu
P2860
P356
10.1126/SCISIGNAL.2001225
P50
P577
2011-01-25T00:00:00Z