Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. - Test2 - elhamkhani - TriplyDB

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

http://www.wikidata.org/entity/Q37215386

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The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies In silico model-based inference: a contemporary approach for hypothesis testing in network biology Cilium assembly and disassembly Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.An epigenetically distinct breast cancer cell subpopulation promotes collective invasion Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells.Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.The development of highly potent inhibitors for porcupine.The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer.The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.LKB1 and AMPK differentially regulate pancreatic β-cell identity.Modeling human disease in humans: the ciliopathies.Identification of therapeutic small-molecule leads in cultured cells using multiplexed pathway reporter readouts The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.Can we safely target the WNT pathway?Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome.Proteomics of Primary Cilia by Proximity Labeling AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma.Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis.Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation.LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma.Requirement for stromal estrogen receptor alpha in cervical neoplasia Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex.Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms.Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells.LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.The Yes-associated protein controls the cell density regulation of Hedgehog signaling KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition.Cell biology. The unusual case of Porcupine.DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway.Targeting Class I Histone Deacetylases by the Novel Small Molecule Inhibitor 4SC-202 Blocks Oncogenic Hedgehog-GLI Signaling and Overcomes Smoothened Inhibitor Resistance.Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.

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Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

http://www.wikidata.org/entity/Q37215386

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 25 January 2011

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.

@en

Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.

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type

label

Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.

@en

Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.

@nl

prefLabel

Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.

@en

Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling.

@nl

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SCISIGNAL.2001225

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Science Signaling

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Genome-wide RNAi screen reveal ...... to Hedgehog and Wnt signaling

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Baolin Wang

http://www.w3.org/2001/XMLSchema#string

Baozhi Chen

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Chih-Wei Fan

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James F Amatruda

http://www.w3.org/2001/XMLSchema#string

Lawrence Lum

http://www.w3.org/2001/XMLSchema#string

Leni S Jacob

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Michael E Dodge

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Ozlem Kulak

http://www.w3.org/2001/XMLSchema#string

Xiaofeng Wu

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

Wnt/beta-catenin signaling: components, mechanisms, and diseases

A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

HEF1-dependent Aurora A activation induces disassembly of the primary cilium

Vertebrate Smoothened functions at the primary cilium.

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

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ra4

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10.1126/SCISIGNAL.2001225

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157

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2011-01-25T00:00:00Z

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