Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.
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Functional enhancement and protection of dopaminergic terminals by RAB3B overexpressionNeurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500APharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's DiseaseParkinson's disease gene therapy: success by design meets failure by efficacyM1 and M2 immune activation in Parkinson's Disease: Foe and ally?Sex differences in Parkinson's diseaseNeuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunityα-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter.The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseaseSmall molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophyTowards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in MacaqueDiabetes alters KIF1A and KIF5B motor proteins in the hippocampusAltered transcription factor trafficking in oxidatively-stressed neuronal cells.Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy.α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neuronsMicrotubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotectiveα-Synuclein oligomers impair neuronal microtubule-kinesin interplay.Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protectionα-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP productionProgressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's diseaseA pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.Riboswitch-mediated Attenuation of Transgene Cytotoxicity Increases Adeno-associated Virus Vector Yields in HEK-293 Cells.Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease.Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathiesNigrostriatal dynein changes in A53T alpha-synuclein transgenic mice.Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease.Versatile somatic gene transfer for modeling neurodegenerative diseases.Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model tα-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.In vivo demonstration that alpha-synuclein oligomers are toxic.Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice.The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.A microRNA embedded AAV α-synuclein gene silencing vector for dopaminergic neurons.Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death.A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
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P2860
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on March 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
@da
vědecký článek
@cs
name
Dynamic changes in presynaptic ...... of AAV alpha-synucleinopathy.
@en
Dynamic changes in presynaptic ...... of AAV alpha-synucleinopathy.
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type
label
Dynamic changes in presynaptic ...... of AAV alpha-synucleinopathy.
@en
Dynamic changes in presynaptic ...... of AAV alpha-synucleinopathy.
@nl
prefLabel
Dynamic changes in presynaptic ...... of AAV alpha-synucleinopathy.
@en
Dynamic changes in presynaptic ...... of AAV alpha-synucleinopathy.
@nl
P2093
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P1476
Dynamic changes in presynaptic ...... l of AAV alpha-synucleinopathy
@en
P2093
Chee Yeun Chung
Hasan Siddiqi
James B Koprich
P2860
P304
P356
10.1523/JNEUROSCI.5427-08.2009
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P50
P577
2009-03-01T00:00:00Z