The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
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Biochemical Genetic Pathways that Modulate Aging in Multiple SpeciesCreating a "Prosurvival Phenotype" Through Histone Deacetylase Inhibition: Past, Present, and FutureCommon features of chromatin in aging and cancer: cause or coincidence?Sirtuins in hematological aging and malignancySIRTain regulators of premature senescence and accelerated agingNonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylasesExpression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patientsATRA-induced cellular differentiation and CD38 expression inhibits acquisition of BCR-ABL mutations for CML acquired resistanceRapid communication: A microRNA-132/212 pathway mediates GnRH activation of FSH expressionA Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer CellsHistones and their modifications in ovarian cancer - drivers of disease and therapeutic targets.Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activityDesynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection.Sirtuins: guardians of mammalian healthspan.SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activationAlisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cellsDown-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1.Gambogic Acid lysinate induces apoptosis in breast cancer mcf-7 cells by increasing reactive oxygen species.Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice.Global profiling of metabolic adaptation to hypoxic stress in human glioblastoma cells.Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease.Reversible modulation of SIRT1 activity in a mouse strain.Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent PathwayMEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilizationRadiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model.SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation.SIRT1-mediated downregulation of p27Kip1 is essential for overcoming contact inhibition of Kaposi's sarcoma-associated herpesvirus transformed cellsNovel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach.Sirtuins and the Metabolic Hurdles in Cancer.Expression profile of SIRT2 in human melanoma and implications for sirtuin-based chemotherapy.Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions.Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL).A novel role of SIRT1 in gammaherpesvirus latency and replication.SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.Tenovin-6 inhibits proliferation and survival of diffuse large B-cell lymphoma cells by blocking autophagy.Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsisPrognostic and clinicopathologic significance of SIRT1 expression in hepatocellular carcinoma.SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells.Inflammation contributes to NKX3.1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression.
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The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 08 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
@en
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
@nl
type
label
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
@en
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
@nl
prefLabel
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
@en
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
@nl
P2093
P2860
P356
P1476
The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
@en
P2093
Hongfeng Yuan
Wen Yong Chen
P2860
P304
P356
10.2147/OTT.S37750
P407
P577
2013-10-08T00:00:00Z