The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway.
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Human diseases of the SSU processomeCurrent concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatmentGuarding the 'translation apparatus': defective ribosome biogenesis and the p53 signaling pathwayLoss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamicsMutant WDR36 directly affects axon growth of retinal ganglion cells leading to progressive retinal degeneration in miceLoss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response.Zebrafish models of p53 functions.Role of the nucleolus in neurodegenerative diseases with particular reference to the retina: a review.Tbl3 regulates cell cycle length during zebrafish development.Glaucoma: genes, phenotypes, and new directions for therapy.Mouse models of retinal ganglion cell death and glaucoma.Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafishTranslational models of ocular disease.p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood CirrhosisThe Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine.Toward a better understanding of human eye disease insights from the zebrafish, Danio rerio.Nom1 mediates pancreas development by regulating ribosome biogenesis in zebrafish.Genetic association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1/SIX6 with the endophenotypes of primary open angle glaucoma in Indian population.WDR36 variants in East Indian primary open-angle glaucoma patientsThe visual system of zebrafish and its use to model human ocular diseases.Copy number variations and primary open-angle glaucoma.WDR36 and P53 gene variants and susceptibility to primary open-angle glaucoma: analysis of gene-gene interactions.Different WDR36 mutation pattern in Chinese patients with primary open-angle glaucomaGlaucoma genetics.Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism.Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development.Complex genetic mechanisms in glaucoma: an overviewA new PICTure of nucleolar stress.Animal models of glaucoma.Genetics of primary open angle glaucoma.Functional architecture of the retina: development and disease.Association of WDR36 polymorphisms with primary open angle glaucoma: A systematic review and meta-analysis.The zebrafish eye-a paradigm for investigating human ocular genetics.Major review: Molecular genetics of primary open-angle glaucoma.RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance.Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.Co-variation of STI1 and WDR36/UTP21 alters cell proliferation in a glaucoma model.An Application of NGS for WDR36 Gene in Taiwanese Patients with Juvenile-Onset Open-Angle Glaucoma.Lessons from ten years of genome-wide association studies of asthma.The Evolution of the Ribosomal Protein-MDM2-p53 Pathway.
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The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 May 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The primary open-angle glaucom ...... e p53 stress-response pathway.
@en
The primary open-angle glaucom ...... e p53 stress-response pathway.
@nl
type
label
The primary open-angle glaucom ...... e p53 stress-response pathway.
@en
The primary open-angle glaucom ...... e p53 stress-response pathway.
@nl
prefLabel
The primary open-angle glaucom ...... e p53 stress-response pathway.
@en
The primary open-angle glaucom ...... e p53 stress-response pathway.
@nl
P2860
P356
P1476
The primary open-angle glaucom ...... e p53 stress-response pathway.
@en
P2093
Brian A Link
Jonathan M Skarie
P2860
P304
P356
10.1093/HMG/DDN147
P577
2008-05-10T00:00:00Z