Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress
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Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implicationsMechanisms of islet amyloidosis toxicity in type 2 diabetesThe Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPPEndoplasmic reticulum stress and type 2 diabetesOn the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP PeptidesChaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpressionBridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive PotentialProtective unfolded protein response in human pancreatic beta cells transplanted into mice.Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets.Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.Quantifying β-cells in health and disease: the past, the present, and the need.β-Cell failure in type 2 diabetes: a case of asking too much of too few?Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics.Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.The role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus.One year of sitagliptin treatment protects against islet amyloid-associated β-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice.Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes.Beta-cell deterioration during diabetes: what's in the gun?Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology.Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetesEndoplasmic reticulum stress and pancreatic β-cell death.Localized amyloids important in diseases outside the brain--lessons from the islets of Langerhans and the thoracic aorta.The role of the unfolded protein response in diabetes mellitus.Apoptosis Repressor with Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation.Involvement of ATP-sensitive potassium (K(ATP)) channels in the loss of beta-cell function induced by human islet amyloid polypeptide.Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets.Insulin concerns and promises.Amyloid-induced β-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment.RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity.The Receptor for Advanced Glycation Endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and Exploiting Common Ground for Novel Amyloidosis Therapies.
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Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Amyloid formation in human IAP ...... h endoplasmic reticulum stress
@en
Amyloid formation in human IAP ...... endoplasmic reticulum stress.
@nl
type
label
Amyloid formation in human IAP ...... h endoplasmic reticulum stress
@en
Amyloid formation in human IAP ...... endoplasmic reticulum stress.
@nl
prefLabel
Amyloid formation in human IAP ...... h endoplasmic reticulum stress
@en
Amyloid formation in human IAP ...... endoplasmic reticulum stress.
@nl
P2093
P2860
P1433
P1476
Amyloid formation in human IAP ...... h endoplasmic reticulum stress
@en
P2093
J Udayasankar
S L Subramanian
P2860
P2888
P304
P356
10.1007/S00125-009-1329-4
P577
2009-04-08T00:00:00Z