mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. - Test2 - elhamkhani - TriplyDB

mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc.

mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc.

http://www.wikidata.org/entity/Q37341834

about

Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect PI3K and AKT: Unfaithful Partners in Cancer MYC, Metabolism, and Cancer MYC and metabolism on the path to cancer Redox regulation of FoxO transcription factors Integrating canonical and metabolic signalling programmes in the regulation of T cell responses Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma.mTORC2 in the center of cancer metabolic reprogramming The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function Cancer metabolism as a central driving force of glioma pathogenesis mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling.Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss.A unique four-hub protein cluster associates to glioblastoma progression.Tumor cells switch to mitochondrial oxidative phosphorylation under radiation via mTOR-mediated hexokinase II inhibition--a Warburg-reversing effect TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression.Metabolic circuits in neural stem cells.Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.mTORC2 is required for rit-mediated oxidative stress resistance.Arsenic trioxide sensitizes glioblastoma to a myc inhibitor.Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells.Significance of filamin A in mTORC2 function in glioblastoma Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability.The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance.EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment.The hypomethylating agent decitabine prior to chemotherapy improves the therapy efficacy in refractory/relapsed acute myeloid leukemia patients.DINGO: differential network analysis in genomics Computational Inferences of the Functions of Alternative/Noncanonical Splice Isoforms Specific to HER2+/ER-/PR- Breast Cancers, a Chromosome 17 C-HPP Study.Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections

P2860

Q26745461-C604328B-F7D1-4B11-9381-3F5606CC0A4C Q26781367-BF00C863-AF3E-44C5-A77E-5E5DC531E98C Q26783555-70E5B6EC-F106-4FDE-AEE6-77FACEB6D7CD Q26798086-5D288F8D-B039-4B10-9BD1-B8CEC959D520 Q26799843-60B66E71-942B-4AC7-9F7E-9EDF6ABD606A Q26851446-F670DA85-D2DF-4162-881C-E4EFDF24790A Q27013006-76B63C13-4DFE-4C44-ADE9-92601EFA6C0C Q28542016-E84CC581-4CF8-48F4-B1E0-7D5D7ABFB474 Q28544009-FA0B0E93-BF7B-499C-A6CB-4E479C2F0BDA Q30235555-32BCD292-6E12-4639-AF5D-342EAF8B8A43 Q33798469-139D4011-443A-416D-978F-9624C70AC4EA Q33829265-565773C0-6355-48B2-BDA3-191FBD9920D3 Q33831466-8C14DD3A-1443-4536-B742-7AA37602D3CF Q33838591-E1DA532E-F857-4ABB-8404-95798004C462 Q33847616-9D07181A-D35F-40A5-8F7D-AB8BEE119E74 Q33884658-42CF517E-F9D1-46DF-9908-F69B60481931 Q34080562-320FE47E-58A9-4D68-9164-905DCB0C7491 Q34364808-936C23B2-B6F8-4DBE-8186-B01C247D4DFA Q34974398-67B94E0B-492B-4ED9-9FB7-447C4F83F707 Q35069561-5E537610-3C56-4605-98F1-AC133520AB67 Q35149656-39D9D435-F6C8-4A8E-BA1A-ED24D4F19A2C Q35210961-1DA921C0-77E2-4AE6-8E03-06694B59BA79 Q35217017-AD3D3ECB-A8E1-47DD-B790-3A6601A9A34F Q35354812-CAFABF56-9BEE-4260-B6AB-2091759A5FDF Q35382648-C7197176-4390-4B2B-A3AC-B6356BE1972C Q35408838-15B79DD3-4855-4C70-B7EF-82E7E0398E84 Q35532313-51A39192-59F7-4E24-83D9-6789BADBED8C Q35650870-7AED5781-7D76-4421-8CCF-2AC68BE69EAC Q35691988-0B591883-DA9E-4FAC-AABE-FB0A4D51C14A Q35809950-01E60F15-9F0F-44C6-95EB-B3A54E77D93F Q35889906-2D71DBD9-5E51-4F09-BEF4-F312A36A82CE Q35894095-E845DA6C-AEC7-4ED6-A39C-664C747FE147 Q35910243-676EB4E5-8AF0-4381-81CB-F40E19D62322 Q36172699-1B5414B8-2DDF-4D13-8649-4E04AC2DEA89 Q36247876-0C8E9841-0347-4A7A-8B99-12AAEEF05AB0 Q36256815-7CBA2A96-CE1C-4D2D-BF69-2E6A295B78F7 Q36545229-C821B2B8-4383-49EA-9853-C658068DCEB8 Q36573647-5E8D10C0-B3AF-415A-89EE-20ABCCA5716B Q36596946-5CD4883E-8BCC-42B5-9010-C1DDDC4C5106 Q36601779-73AD0923-1BE8-477E-BD38-1117BB1BB3E8

P2860

mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc.

http://www.wikidata.org/entity/Q37341834

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 17 October 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

mTOR complex 2 controls glycol ...... ion and upregulation of c-Myc.

@en

mTOR complex 2 controls glycol ...... ion and upregulation of c-Myc.

@nl

type

label

mTOR complex 2 controls glycol ...... ion and upregulation of c-Myc.

@en

mTOR complex 2 controls glycol ...... ion and upregulation of c-Myc.

@nl

prefLabel

mTOR complex 2 controls glycol ...... ion and upregulation of c-Myc.

@en

mTOR complex 2 controls glycol ...... ion and upregulation of c-Myc.

@nl

P1433

Q37341834-B165D2D8-79E0-4242-8D50-4645C5D5CF02

P1476

Q37341834-798B3F42-E84F-47B3-897E-8AF81607F1ED

P2093

Q37341834-0586E4E8-2A95-425C-A96F-12787B3666FC

Q37341834-05DFC9D8-BAB8-4814-AC10-AAE89CEE9824

Q37341834-0FEB2251-D9DA-4451-A654-55A6525B4EDB

Q37341834-21956358-5C41-4AA2-9B98-CA1050FDA760

Q37341834-2D25E6DE-5A10-4C70-89BB-1ABE9A6FD6C2

Q37341834-53B5E4B2-5722-4CC3-9A53-B2FE9F2D7C66

Q37341834-54D963EA-5E60-4328-91FD-7FC33BBC3A8C

Q37341834-55D6ED2E-70E7-48F5-9842-4AC563AEF2AE

Q37341834-5BA72401-75CD-448C-AB78-C86083D5BB3B

Q37341834-64B07882-CA49-4AEC-8426-71E9BEE604D5

P2860

Q37341834-01BA3C06-FBC8-4F82-BC2C-C0A361B5E00D

Q37341834-0228C7BA-4C61-4B28-ADED-3B4ACAA988C0

Q37341834-04BD0033-2BDB-42E1-8274-FD6BF96C8F48

Q37341834-055A2B6A-DA6A-4401-BB41-8B3559EE6A26

Q37341834-06B8A590-702B-4D9F-B361-7762898BD2C0

Q37341834-0AFF07B5-96E2-436B-B6AD-85D86DBB99CC

Q37341834-10CFC576-52A2-4F42-A8FF-EFF640333E56

Q37341834-14627CF4-2B6E-4B47-8C74-163458248168

Q37341834-271D7294-75CE-42E0-90EE-B997453C1703

Q37341834-2B0ED3FE-C868-4A96-98EC-1DA711CDAD6A

P304

Q37341834-76EB0EAF-153F-45B8-BFC1-9D74DDCA0AE8

P31

Q37341834-CBC5D988-C000-45DB-9FDD-149803F2CA9C

P356

Q37341834-AE305E2F-646C-48BD-ABCF-0B80E75FAB22

P433

Q37341834-39FB49FC-1CED-46F8-8696-89092BF30165

P478

Q37341834-A9A6F1B0-02D0-4A4B-BC2C-6396EFCB555F

P50

Q37341834-FDDCC7C6-8952-415F-99F3-F3027B7D8B57

P577

Q37341834-4CC29481-012D-434A-9A78-0933342FE446

P5875

Q37341834-14FF9B61-8FE3-4BBC-BC87-C8BA515D2ED4

P698

Q37341834-B52B666E-7C24-4419-BB20-908392E2573E

P932

Q37341834-DA129F81-5C95-443A-A7DE-28E1275AA4BF

P356

J.CMET.2013.09.013

P1433

Cell Metabolism

P1476

mTOR complex 2 controls glycol ...... ion and upregulation of c-Myc.

@en

P2093

Akio Iwanami

http://www.w3.org/2001/XMLSchema#string

Beatrice Gini

http://www.w3.org/2001/XMLSchema#string

David Akhavan

http://www.w3.org/2001/XMLSchema#string

Feng Liu

http://www.w3.org/2001/XMLSchema#string

Genaro R Villa

http://www.w3.org/2001/XMLSchema#string

Huijun Yang

http://www.w3.org/2001/XMLSchema#string

Ingo K Mellinghoff

http://www.w3.org/2001/XMLSchema#string

Ivan Babic

http://www.w3.org/2001/XMLSchema#string

Kazuhiro Tanaka

http://www.w3.org/2001/XMLSchema#string

Kenta Masui

http://www.w3.org/2001/XMLSchema#string

P2860

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Links between metabolism and cancer

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers

Pyruvate kinase M2 is a phosphotyrosine-binding protein

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

P304

726-739

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.CMET.2013.09.013

http://www.w3.org/2001/XMLSchema#string

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

18

http://www.w3.org/2001/XMLSchema#string

P50

P577

2013-10-17T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

258059344

http://www.w3.org/2001/XMLSchema#string

P698

24140020

http://www.w3.org/2001/XMLSchema#string

P932

3840163

http://www.w3.org/2001/XMLSchema#string