Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo.
about
Maternal vasodilation in pregnancy: the emerging role of relaxinThe renal circulation in normal pregnancy and preeclampsia: is there a place for relaxin?Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivoInterstitial fibrosis and growth factorsRelaxin is a key mediator of prostate growth and male reproductive tract developmentRole of sphingosine kinase/S1P axis in ECM remodeling of cardiac cells elicited by relaxinRelaxin is a potent renal vasodilator in conscious rats.Organising pneumonia.T lymphocyte and fibroblast interactions: the case of skin involvement in systemic sclerosis and other examples.Relaxin: antifibrotic properties and effects in models of diseaseRelaxin signaling in uterine fibroids.Combination therapies for systemic sclerosis.Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS.Molecular mechanisms of renal allograft fibrosis.Potential methods to prevent interstitial fibrosis in renal disease.Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumabRelaxin induces matrix-metalloproteinases-9 and -13 via RXFP1: induction of MMP-9 involves the PI3K, ERK, Akt and PKC-ζ pathwaysSerelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteinsRelaxin regulates vascular wall remodeling and passive mechanical properties in mice.Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrotic lungsInternational Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.The minimal active structure of human relaxin-2Relaxin and beta-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss.Relaxin regulates myofibroblast contractility and protects against lung fibrosisRelaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat.Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway.Constitutive formation of an RXFP1-signalosome: a novel paradigm in GPCR function and regulation.Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.Role of relaxin in maternal renal vasodilation of pregnancy.Relaxin is essential for renal vasodilation during pregnancy in conscious ratsMechanisms of renal vasodilation and hyperfiltration during pregnancy: current perspectives and potential implications for preeclampsia.The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate.Relaxin as a natural agent for vascular healthCombining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease.The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?Relaxin treatment of solid tumors: effects on electric field-mediated gene delivery.Pharmacotherapy of acute lung injury and acute respiratory distress syndromeAging and the cardiac collagen matrix: Novel mediators of fibrotic remodellingRelaxin treatment reverses insulin resistance in mice fed a high-fat diet3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers
P2860
Q24618633-8C6C991C-F828-4190-BCB8-0E7EE4A4BCC7Q27003301-2995E81C-231D-4942-BB13-0341F49FBEF0Q28353986-7369C50C-2D49-41EE-B4BC-14F25F37BB12Q28391906-D62B3F49-FF90-4477-8E11-9FDC7466DD5DQ28586427-BC58B91D-4248-43D0-8A23-34544169B93FQ33631848-D862DD65-3F02-4D6F-A926-D1247A7EBF78Q33843076-4A896F5A-8FC7-495E-AF90-861BCF556ED3Q33866504-95C0B682-036E-4403-B93B-9327E881896FQ34005615-37B3B1E3-6117-4894-88B8-A12A37F45211Q34146511-04AC8DA0-F960-4DEC-BC10-DFF9AAD9A7FAQ34197050-A37099DA-8F10-420C-B41B-4E86A5D35318Q34309698-60647E0A-20BF-4D22-98B2-BB002B7AE2DEQ34398874-386992F0-9741-46B5-9385-0841ECEBA457Q34421501-5633B8E2-FC3D-40D7-950E-D54BB2BFB8BEQ34481843-0831F269-C7B8-43E2-A265-F41C632E1090Q34621713-91A099D7-CE35-488A-B29B-41C9A5B84DEFQ34640853-6B235E9C-80D3-495D-B485-663D2BD28270Q35039209-1B22930A-012A-4108-AACD-7622FF210D2CQ35108756-2B82C7A3-86E4-4B68-BC94-BDA8094F1518Q35351530-33BC4353-E912-4681-91B0-41CCCF402EF5Q35383835-C99340BA-FC97-476D-918A-1E794DC0DD27Q35423895-BD00BF7F-6437-4045-BBF3-95160D418A03Q35605529-06019400-B936-4806-87B0-8CE5AFC6BBDBQ35679329-1BF17FA0-94B6-42DD-974F-65F53331BD33Q35939966-6AE3B01D-1AF9-435B-ADD4-38934818A27CQ35970597-12A03B29-9F81-4F29-A379-1EE611144E39Q36025314-D0BAF12F-7E55-4DBE-A00C-C97BF8E68773Q36078699-327A0694-562F-4B28-8974-EF7C0FBA91D5Q36163300-F116FF38-2C1A-4639-90C0-2E79DBF2C0EEQ36167196-8C595C7E-4D0E-44A2-8F88-A849EF3B1DBAQ36203507-38DFCC34-62FE-49B8-860C-84B8E887D707Q36749450-BAB3BC59-FD0C-488E-85B1-BA753FF34600Q36835818-249EF39C-F692-4475-8433-4D44F0CEAC37Q36941251-011CFC5A-42FF-4B6C-9FEA-F0541C493C3AQ36970923-CA1D3CCE-A2DA-4E5E-A7A5-5ECEB3C9BEB6Q37000549-0303E0B6-4483-4BEB-AF4F-95BB014A2BC7Q37085611-D936D3B2-1AD9-4421-86AD-6AD9D342054EQ37096257-5B12A8C2-CB05-4795-ABA1-FB8824742968Q37110579-803E914A-4447-4420-993A-0242DE95794BQ37120582-91840299-F1D9-4B22-B531-C4D9B2A7F819
P2860
Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Relaxin induces an extracellul ...... sis in a murine model in vivo.
@en
Relaxin induces an extracellul ...... sis in a murine model in vivo.
@nl
type
label
Relaxin induces an extracellul ...... sis in a murine model in vivo.
@en
Relaxin induces an extracellul ...... sis in a murine model in vivo.
@nl
prefLabel
Relaxin induces an extracellul ...... sis in a murine model in vivo.
@en
Relaxin induces an extracellul ...... sis in a murine model in vivo.
@nl
P2093
P2860
P356
P1476
Relaxin induces an extracellul ...... sis in a murine model in vivo.
@en
P2093
Erikson ME
Pickford LB
Unemori EN
P2860
P304
P356
10.1172/JCI119099
P407
P577
1996-12-01T00:00:00Z