A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open.
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Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists.Structural determinants of 5',6'-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel.Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation.
P2860
A competing hydrophobic tug on L596 to the membrane core unlatches S4-S5 linker elbow from TRP helix and allows TRPV4 channel to open.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 October 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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A competing hydrophobic tug on ...... allows TRPV4 channel to open.
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A competing hydrophobic tug on ...... allows TRPV4 channel to open.
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type
label
A competing hydrophobic tug on ...... allows TRPV4 channel to open.
@en
A competing hydrophobic tug on ...... allows TRPV4 channel to open.
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A competing hydrophobic tug on ...... allows TRPV4 channel to open.
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A competing hydrophobic tug on ...... allows TRPV4 channel to open.
@nl
P2093
P2860
P356
P1476
A competing hydrophobic tug on ...... allows TRPV4 channel to open.
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P2093
Andriy Anishkin
Ching Kung
Jinfeng Teng
Stephen H Loukin
P2860
P304
11847-11852
P356
10.1073/PNAS.1613523113
P407
P577
2016-10-03T00:00:00Z