Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
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Aggrecanases and cartilage matrix degradationArticular cartilage and changes in arthritis: matrix degradation.What can we do about osteoarthritis?The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorptionThe role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritisMatrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)ADAMTS-1 cleaves a cartilage proteoglycan, aggrecanMembrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domainNon-enzymatic decomposition of collagen fibers by a biglycan antibody and a plausible mechanism for rheumatoid arthritisAggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.Effects of intraarticular glucocorticoids on macrophage infiltration and mediators of joint damage in osteoarthritis synovial membranes: findings in a double-blind, placebo-controlled study.Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments.Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.The use of cleavage site specific antibodies to delineate protein processing and breakdown pathways.Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activityMatrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage.The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models.Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.Metabolism of cartilage proteoglycans in health and diseaseADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.Structure and function of aggrecan.Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5Internalization of aggrecan G1 domain neoepitope ITEGE in chondrocytes requires CD44Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implicationsAggrecanolysis and in vitro matrix degradation in the immature bovine meniscus: mechanisms and functional implications.Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro studyThe accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan.ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeuticsType II collagen degradation and its regulation in articular cartilage in osteoarthritisChondroprotective Effect of Kartogenin on CD44-Mediated Functions in Articular Cartilage and ChondrocytesAn ultrasound study of altered hydration behaviour of proteoglycan-degraded articular cartilagePrevention of progressive joint destruction in collagen-induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR255031.Extracellular processing of the cartilage proteoglycan aggregate and its effect on CD44-mediated internalization of hyaluronanProteases involved in cartilage matrix degradation in osteoarthritis.CleavPredict: A Platform for Reasoning about Matrix Metalloproteinases Proteolytic Events.An enzyme-sensitive PEG hydrogel based on aggrecan catabolism for cartilage tissue engineering
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P2860
Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1997
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Aggrecan degradation in human ...... hritic, and rheumatoid joints.
@en
Aggrecan degradation in human ...... hritic, and rheumatoid joints.
@nl
type
label
Aggrecan degradation in human ...... hritic, and rheumatoid joints.
@en
Aggrecan degradation in human ...... hritic, and rheumatoid joints.
@nl
prefLabel
Aggrecan degradation in human ...... hritic, and rheumatoid joints.
@en
Aggrecan degradation in human ...... hritic, and rheumatoid joints.
@nl
P2093
P2860
P356
P1476
Aggrecan degradation in human ...... hritic, and rheumatoid joints.
@en
P2093
Donatelli SA
Flanagan J
Hoerrner LA
Hutchinson NI
Lohmander LS
Mumford RA
P2860
P304
P356
10.1172/JCI119526
P407
P577
1997-07-01T00:00:00Z