B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.
about
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.TYK2 is a key regulator of the surveillance of B lymphoid tumorsMethylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemiaROR1, an embryonic protein with an emerging role in cancer biologyScreening approaches to generating STAT inhibitors: Allowing the hits to identify the targetsSerine phosphorylation and negative regulation of Stat3 by JNKProline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells.Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation.Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells.STAT signaling in the pathogenesis and treatment of cancerStimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells.Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.STAT signaling in the pathogenesis and treatment of leukemias.Serine phosphorylation of STATs.Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation.STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells.Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformationThe synergy between stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF): molecular basis and clinical relevance.STAT3-activated GM-CSFRα translocates to the nucleus and protects CLL cells from apoptosis.The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules.STAT proteins: novel molecular targets for cancer drug discovery.STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypesViability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727.Signal transducer and activator of transcription-3 induces microRNA-155 expression in chronic lymphocytic leukemia.Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia.The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformationAcute pancreatitis with organ dysfunction associates with abnormal blood lymphocyte signaling: controlled laboratory study.The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer.Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells.Nucleoside transporters in chronic lymphocytic leukaemia.Protein kinases in the regulation of apoptosis in B-cell chronic lymphocytic leukemia.Constitutive STAT3 Phosphorylation in Circulating CD4+ T Lymphocytes Associates with Disease Activity and Treatment Response in Recent-Onset Rheumatoid Arthritis.Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesisMicroenvironmental interactions and survival of CLL B-cells.
P2860
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P2860
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
B lymphocytes from patients wi ...... phorylated on serine residues.
@en
B lymphocytes from patients wi ...... and activator of transcription
@nl
type
label
B lymphocytes from patients wi ...... phorylated on serine residues.
@en
B lymphocytes from patients wi ...... and activator of transcription
@nl
prefLabel
B lymphocytes from patients wi ...... phorylated on serine residues.
@en
B lymphocytes from patients wi ...... and activator of transcription
@nl
P2860
P921
P356
P1476
B lymphocytes from patients wi ...... sphorylated on serine residues
@en
P2093
P2860
P304
P356
10.1172/JCI119869
P407
P50
P577
1997-12-01T00:00:00Z