about
The cellular and molecular basis for malaria parasite invasion of the human red blood cellInvasion by P. falciparum merozoites suggests a hierarchy of molecular interactionsThe mechanics of malaria parasite invasion of the human erythrocyte - towards a reassessment of the host cell contributionA conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasitesPlasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domainsDisassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites.Spatial localisation of actin filaments across developmental stages of the malaria parasiteMinimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1The dendritic cell receptor Clec9A binds damaged cells via exposed actin filamentsCryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetineBiosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasionCell-cell communication between malaria-infected red blood cells via exosome-like vesiclesPfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite divisionMalaria parasite signal peptide peptidase is an ER-resident protease required for growth but not for invasionSystematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparumPfSec13 is an unusual chromatin-associated nucleoporin of Plasmodium falciparum that is essential for parasite proliferation in human erythrocytesAn EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparumSubcompartmentalisation of proteins in the rhoptries correlates with ordered events of erythrocyte invasion by the blood stage malaria parasitePlasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasionA mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interfacePlasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasitesMolecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites.Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytesCryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast.Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum.Plasmodium actin is incompletely folded by heterologous protein-folding machinery and likely requires the native Plasmodium chaperonin complex to enter a mature functional state.Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screenInteraction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites.Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development.Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyteElectron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion.Erythrocyte invasion phenotypes of Plasmodium falciparum in The Gambia.Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility.Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum.Signal-mediated export of proteins from the malaria parasite to the host erythrocyte.Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton.Regulation of apicomplexan actin-based motility.Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparumReassessing the mechanics of parasite motility and host-cell invasion.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Jake Baum
@ast
Jake Baum
@en
Jake Baum
@es
Jake Baum
@nl
Jake Baum
@sl
type
label
Jake Baum
@ast
Jake Baum
@en
Jake Baum
@es
Jake Baum
@nl
Jake Baum
@sl
altLabel
Jacob Baum
@en
prefLabel
Jake Baum
@ast
Jake Baum
@en
Jake Baum
@es
Jake Baum
@nl
Jake Baum
@sl
P106
P21
P31
P4012
P496
0000-0002-0275-352X