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SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformationMethylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.Paired single residue-transposed Lys-N and Lys-C digestions for label-free identification of N-terminal and C-terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectThe first pilot project of the consortium for top-down proteomics: a status report.One-pot shotgun quantitative mass spectrometry characterization of histonesChemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.A novel approach for untargeted post-translational modification identification using integer linear optimization and tandem mass spectrometry.Proteomic interrogation of human chromatin.Quantitative proteomic approaches to studying histone modifications.Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a.The N-terminal Domain of Escherichia coli Assimilatory NADPH-Sulfite Reductase Hemoprotein Is an Oligomerization Domain That Mediates Holoenzyme Assembly.Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cellsAsymmetrically modified nucleosomesNucleotide-induced conformational changes of tetradecameric GroEL mapped by H/D exchange monitored by FT-ICR mass spectrometryQuantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical DependenceDNA Interactions Probed by Hydrogen-Deuterium Exchange (HDX) Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Confirm External Binding Sites on the Minichromosomal Maintenance (MCM) Helicase.Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.High throughput characterization of combinatorial histone codes.A mixed integer linear optimization framework for the identification and quantification of targeted post-translational modifications of highly modified proteins using multiplexed electron transfer dissociation tandem mass spectrometry.Protected amine labels: a versatile molecular scaffold for multiplexed nominal mass and sub-Da isotopologue quantitative proteomic reagents.Systems-wide proteomic characterization of combinatorial post-translational modification patterns.The significance, development and progress of high-throughput combinatorial histone code analysis.Methylation of H2AR29 is a novel repressive PRMT6 targetMapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry.Label-Free Relative Quantitation of Isobaric and Isomeric Human Histone H2A and H2B Variants by Fourier Transform Ion Cyclotron Resonance Top-Down MS/MS.Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications.Epitope mapping of 7S cashew antigen in complex with antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry.Rapid screening for potential epitopes reactive with a polycolonal antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry.Method to site-specifically identify and quantitate carbonyl end products of protein oxidation using oxidation-dependent element coded affinity tags (O-ECAT) and nanoliquid chromatography Fourier transform mass spectrometry.Ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo amino acid sequencing for a seven-protein mixture by paired single-residue transposed Lys-N and Lys-C digestion.How many human proteoforms are there?Ultraviolet photodissociation enhances top-down mass spectrometry as demonstrated on green fluorescent protein variants.Middle-Down Characterization of the Cell Cycle Dependence of Histone H4 Post-Translational Modifications and Proteoforms.The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance.Control of Hexamerization, Assembly, and Excluded Strand Specificity for the Sulfolobus solfataricus MCM HelicaseEarly butyrate induced acetylation of histone H4 is proteoform specific and linked to methylation stateAMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemiaHigh-Throughput Quantitative Top-Down Proteomics: Histone H4One-Pot Quantitative Top- and Middle-Down Analysis of GluC-Digested Histone H4Characterization of SETD3 methyltransferase mediated protein methionine methylation
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Nicolas L Young
@es
Nicolas L Young
@nl
Nicolas L Young
@sl
Nicolas L. Young
@en
type
label
Nicolas L Young
@es
Nicolas L Young
@nl
Nicolas L Young
@sl
Nicolas L. Young
@en
altLabel
Nicolas L. Young
@en
Nicolas Leon Young
@en
prefLabel
Nicolas L Young
@es
Nicolas L Young
@nl
Nicolas L Young
@sl
Nicolas L. Young
@en
P106
P1153
55914753000
P21
P31
P496
0000-0002-3323-2815