Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.
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Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasitesThioredoxin glutathione reductase-dependent redox networks in platyhelminth parasitesThe redox biology of schistosome parasites and applications for drug developmentMapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray CrystallographyStructural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoniLeishmanicidal activities of novel synthetic furoxan and benzofuroxan derivatives.Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors.New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni.Schistosomiasis chemotherapy.Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases.High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasisOxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target.Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents.A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents.Oxadiazole-2-oxides may have other functional targets, in addition to SjTGR, through which they cause mortality in Schistosoma japonicumInvestigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni.In vitro screening of compounds against laboratory and field isolates of human hookworm reveals quantitative differences in anthelmintic susceptibility.QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni.Thioredoxin reductase and its inhibitors.Computer-Aided Drug Design Using Sesquiterpene Lactones as Sources of New Structures with Potential Activity against Infectious Neglected Diseases.Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening.Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice.Synthesis and SAR studies of praziquantel derivatives with activity against Schistosoma japonicum.Inhibitory effect of some new uracil and thiouracil derivatives on cercarial penetration enzymesIdentification of Gut Microbial Metabolites of a Synthetic Nitric Oxide-Releasing Farnesylthiosalicylic Acid Derivative, an Antitumor Agent
P2860
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P2860
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on October 2009
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vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Structure mechanism insights a ...... gents against schistosomiasis.
@en
Structure mechanism insights a ...... gents against schistosomiasis.
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type
label
Structure mechanism insights a ...... gents against schistosomiasis.
@en
Structure mechanism insights a ...... gents against schistosomiasis.
@nl
prefLabel
Structure mechanism insights a ...... gents against schistosomiasis.
@en
Structure mechanism insights a ...... gents against schistosomiasis.
@nl
P2093
P2860
P50
P356
P1476
Structure mechanism insights a ...... gents against schistosomiasis.
@en
P2093
Ahmed A Sayed
Craig J Thomas
David J Maloney
David L Williams
Elias S J Arnér
Ganesha Rai
Harinath Chakrapani
James Inglese
Larry Keefer
P2860
P304
P356
10.1021/JM901021K
P407
P577
2009-10-01T00:00:00Z