Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.
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Matrix metalloproteinases in kidney homeostasis and diseasesOcular features in Alport syndrome: pathogenesis and clinical significanceLaminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis.The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.The glomerular basement membrane as a barrier to albumin.Mild electrical stimulation and heat shock ameliorates progressive proteinuria and renal inflammation in mouse model of Alport syndromeUpregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) miceReduced NO signaling during pregnancy attenuates outward uterine artery remodeling by altering MMP expression and collagen and elastin depositionMechanisms and consequences of TGF-ß overexpression by podocytes in progressive podocyte disease.X-Linked Alport Dogs Demonstrate Mesangial Filopodial Invasion of the Capillary Tuft as an Early Event in Glomerular Damage.Glomerular pathology in Alport syndrome: a molecular perspective.Tensin2-deficient mice on FVB/N background develop severe glomerular disease.α1β1 integrin/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome.An update on the pathomechanisms and future therapies of Alport syndrome.Alport syndrome--insights from basic and clinical research.Cell-matrix adhesion of podocytes in physiology and disease.Alport syndrome: its effects on the glomerular filtration barrier and implications for future treatment.Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice.Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome.Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease.The 2014 International Workshop on Alport Syndrome.A model of strain-dependent glomerular basement membrane maintenance and its potential ramifications in health and disease.Characterization of the early molecular changes in the glomeruli of Cd151 -/- mice highlights induction of mindin and MMP-10.STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model.Basement Membrane Defects in Genetic Kidney Diseases.Alport syndrome and Pierson syndrome: Diseases of the glomerular basement membrane.
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Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Biomechanical strain causes ma ...... to Alport glomerular disease.
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Biomechanical strain causes ma ...... to Alport glomerular disease.
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type
label
Biomechanical strain causes ma ...... to Alport glomerular disease.
@en
Biomechanical strain causes ma ...... to Alport glomerular disease.
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prefLabel
Biomechanical strain causes ma ...... to Alport glomerular disease.
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Biomechanical strain causes ma ...... to Alport glomerular disease.
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P2093
P2860
P356
P1433
P1476
Biomechanical strain causes ma ...... to Alport glomerular disease.
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P2093
Daniel T Meehan
Dominic Cosgrove
Duane Delimont
J David Holzclaw
Linda Cheung
Marisa Zallocchi
Steven C Sansom
Velidi Rao
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P2888
P304
P356
10.1038/KI.2009.324
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P577
2009-08-26T00:00:00Z