Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
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Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumorsConditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma.Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice.Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in miceExploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studiesIn vivo proton MR spectroscopy of pancreatic neuroendocrine tumors in a multiple endocrine neoplasia type 1 conditional knockout mouse modelThe Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth.Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).Insulinoma: pathophysiology, localization and managementAAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas.Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis.Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model.GSK-3β protein phosphorylates and stabilizes HLXB9 protein in insulinoma cells to form a targetable mechanism of controlling insulinoma cell proliferation.Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors.Menin and bone metabolism.The future: genetics advances in MEN1 therapeutic approaches and management strategies.Two nonsense somatic mutations in MEN1 identified in sporadic insulinomas.Therapy: Blockade of IGF-1R-not effective in neuroendocrine tumours.Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models.Novel Dual-Action Targeted Nanomedicine in Mice With Metastatic Thyroid Cancer and Pancreatic Neuroendocrine Tumors.ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
P2860
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P2860
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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name
Recapitulation of pancreatic n ...... directed inactivation of Men1.
@en
Recapitulation of pancreatic n ...... directed inactivation of Men1.
@nl
type
label
Recapitulation of pancreatic n ...... directed inactivation of Men1.
@en
Recapitulation of pancreatic n ...... directed inactivation of Men1.
@nl
prefLabel
Recapitulation of pancreatic n ...... directed inactivation of Men1.
@en
Recapitulation of pancreatic n ...... directed inactivation of Men1.
@nl
P2093
P2860
P1433
P1476
Recapitulation of pancreatic n ...... directed inactivation of Men1.
@en
P2093
Allen M Spiegel
Amelia C Grover
Anathea Powell
Charles Heller
Dominique Lorang
H-C Jennifer Shen
Kris Ylaya
Stephen J Marx
P2860
P304
P356
10.1158/0008-5472.CAN-08-3662
P407
P577
2009-02-10T00:00:00Z