Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo. - Test2 - elhamkhani - TriplyDB

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo.

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo.

http://www.wikidata.org/entity/Q37465966

about

Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels-An Ex Vivo Study.Mechanism of microRNA-21 regulating IL-6 inflammatory response and cell autophagy in intervertebral disc degeneration Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development.Mesenchymal Stem Cells Protect Nucleus Pulposus Cells from Compression-Induced Apoptosis by Inhibiting the Mitochondrial Pathway.Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration.Prolactin inhibits the progression of intervertebral disc degeneration through inactivation of the NF-κB pathway in rats.Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model.Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration Ageing, Cellular Senescence and Neurodegenerative Disease

P2860

Q33624944-290B5A03-9E1E-49EE-8916-A8B74ECD78DB Q41116307-08305A3A-7375-40DA-AC83-76D75E01A032 Q41911810-EA8DAA7C-3C7D-45FA-A910-B55800457A1C Q48130011-E8637BE7-EB21-43A4-8120-B0D1536F1E96 Q48204278-E89B59D6-1710-4616-A997-FEB59A3EA64E Q48511601-19CEA1FD-DBA0-4274-B5CF-4558E9C3285A Q55239122-E9275434-9A79-4F4B-8052-E6DD1A7F1216 Q57073792-EB748612-FF8E-4D4E-8D89-989B5D17B1F9 Q58700587-2B5C3C0E-2C5C-4A21-9794-D9D46CDBFDCF Q58761326-5F784C1A-2442-48FB-A106-E88A3F3CBDA0 Q59131971-6D9B750D-C8D4-48E3-9C4B-66E8D31810E4 Q59133878-8745D8C6-93AD-433C-81B0-2718765D9016

P2860

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo.

http://www.wikidata.org/entity/Q37465966

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 27 October 2016

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Metformin protects against apo ...... tes disc degeneration in vivo.

@en

Metformin protects against apo ...... tes disc degeneration in vivo.

@nl

type

label

Metformin protects against apo ...... tes disc degeneration in vivo.

@en

Metformin protects against apo ...... tes disc degeneration in vivo.

@nl

prefLabel

Metformin protects against apo ...... tes disc degeneration in vivo.

@en

Metformin protects against apo ...... tes disc degeneration in vivo.

@nl

P1433

Q37465966-8F636E51-AEA9-4FA0-9211-2F9A8E594ED7

P1476

Q37465966-3E94C7A3-DC55-41E9-AB32-1477E6D4B806

P2093

Q37465966-09E9F89A-8B3D-4D51-8C2E-7B1489D1CC97

Q37465966-12F1F550-E482-4EDD-85CF-259C02863B90

Q37465966-1F4E3FE1-5675-4FD7-A36A-F556B45F76B5

Q37465966-2C6B2983-8109-4112-8658-29FE5173113D

Q37465966-2F3F506B-C839-4F55-AF46-877A16045260

Q37465966-3DC1FA8C-FF01-4B4A-9B23-AA9C45D60272

Q37465966-569D5F36-6F2F-4B47-A46C-4D83C214EC46

Q37465966-729FFAF2-7771-461B-9931-34F1CD8BEE67

Q37465966-90C921F0-9232-4F09-BF78-BAE9043111A3

Q37465966-932C7EBE-1EE7-40E9-9A41-727C82D83F26

P2860

Q37465966-0578DDC7-D93B-4BD8-8C4F-FC5A2E07B127

Q37465966-1473D7CC-1A68-492D-8CDA-D878BE1F7131

Q37465966-1921C159-80C0-4889-99DA-263658953F21

Q37465966-1F1EE721-4FA2-42A4-91F8-FD91930D3FA3

Q37465966-20CB4E8A-89FC-4FF2-8070-EC4714C10C12

Q37465966-236D166A-DAEF-4D01-8470-475D071BAB62

Q37465966-25C2F908-504B-4867-BBEF-E53A123E0C3B

Q37465966-2E0D903B-744B-4AD0-B216-7F4FC60F8B36

Q37465966-2FD7E510-3505-49B6-B028-CAEADA8B1E2E

Q37465966-391174A1-B357-4B08-BCC9-DBBD9D72D901

P304

Q37465966-31C1A2A8-BBB6-45DF-9D61-F12E019B3DDD

P31

Q37465966-5D9C30C4-D1E9-4819-99DA-76BEE73B9C96

P356

Q37465966-87DB3E0F-6DC5-4DCC-B486-DF0759F8F022

P433

Q37465966-9C0A5EA6-F928-4BC1-8A06-454CF1D6FBE7

P478

Q37465966-93A04A00-9693-431A-AAA2-734B76FB59E1

P50

Q37465966-43177A10-D354-4366-AF79-5B48C0A6E139

P577

Q37465966-2BF52397-2F2F-4B7F-BB37-2390CC078B37

P698

Q37465966-A32711A0-0D4D-4A8F-9B9F-BE6EBACCF481

P921

Q37465966-64F0A534-3F6B-44BD-86A7-9AB6FFD4B822

Q37465966-FECF827D-2F1A-4E06-9173-957117FD576F

P932

Q37465966-8EDB5433-D571-493B-A573-DBB0334006AF

P356

P1433

Cell Death and Disease

P1476

Metformin protects against apo ...... ates disc degeneration in vivo

@en

P2093

Chenggui Wang

http://www.w3.org/2001/XMLSchema#string

Daoliang Xu

http://www.w3.org/2001/XMLSchema#string

Deheng Chen

http://www.w3.org/2001/XMLSchema#string

Dongdong Xia

http://www.w3.org/2001/XMLSchema#string

Huazi Xu

http://www.w3.org/2001/XMLSchema#string

Jing Jie Zhang

http://www.w3.org/2001/XMLSchema#string

Kailiang Zhou

http://www.w3.org/2001/XMLSchema#string

Naifeng Tian

http://www.w3.org/2001/XMLSchema#string

Ningyu Cai

http://www.w3.org/2001/XMLSchema#string

Qian Tang

http://www.w3.org/2001/XMLSchema#string

P2860

Autophagy: process and function

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy.

Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice

Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a.

Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload.

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.

Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition.

Stimulation of autophagy promotes functional recovery in diabetic rats with spinal cord injury.

P304

e2441

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/CDDIS.2016.334

http://www.w3.org/2001/XMLSchema#string

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

P577

2016-10-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

27787519

http://www.w3.org/2001/XMLSchema#string

P921

apoptotic process

P932

5133996

http://www.w3.org/2001/XMLSchema#string