The drug transporter-metabolism alliance: uncovering and defining the interplay. - Test2 - elhamkhani - TriplyDB

The drug transporter-metabolism alliance: uncovering and defining the interplay.

The drug transporter-metabolism alliance: uncovering and defining the interplay.

http://www.wikidata.org/entity/Q37485904

about

Fruit juice inhibition of uptake transport: a new type of food-drug interaction Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor BDDCS applied to over 900 drugs.A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells.Influence of dietary substances on intestinal drug metabolism and transport.BDDCS class prediction for new molecular entities.Sucralose, a synthetic organochlorine sweetener: overview of biological issues A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields Incorporation of ABCB1-mediated transport into a physiologically-based pharmacokinetic model of docetaxel in mice.Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings.Transporter-mediated Efflux Influences CNS Side Effects: ABCB1, from Antitarget to Target.Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.Impact of quercetin‑induced changes in drug‑metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in rats Interactions of dietary phytochemicals with ABC transporters: possible implications for drug disposition and multidrug resistance in cancer.Biomagnetic methods: technologies applied to pharmaceutical research.Clearance (née Rowland) concepts: a downdate and an update.Pharmacogenetics of drug transporters in the enterohepatic circulation.Transporter-mediated drug-drug interactions.Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption.The significance of acid/base properties in drug discovery The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development Structure-activity relationships and in silico models of P-glycoprotein (ABCB1) inhibitors.Pharmacokinetic drug interactions involving Ginkgo biloba.Suitability of digoxin as a P-glycoprotein probe: implications of other transporters on sensitivity and specificity.Phase 0 and phase III transport in various organs: combined concept of phases in xenobiotic transport and metabolism.Pharmacogenetics of drug-induced birth defects: the role of polymorphisms of placental transporter proteins.Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research.Computational modeling to predict the functions and impact of drug transporters.Toward a unifying strategy for the structure-based prediction of toxicological endpoints.Reappraisal and perspectives of clinical drug-drug interaction potential of α-glucosidase inhibitors such as acarbose, voglibose and miglitol in the treatment of type 2 diabetes mellitus.Food and Drug Interactions.Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System.The potential of steroids and xenobiotic receptor polymorphisms in forecasting cyclosporine pharmacokinetic variability in young kidney transplant recipients.New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors.Membrane Transporters and Pharmacological Implications Modulation of biotransformation systems and ABC transporters by benznidazole in rats.Drug transport and metabolism in the blood-brain barrier

P2860

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P2860

The drug transporter-metabolism alliance: uncovering and defining the interplay.

http://www.wikidata.org/entity/Q37485904

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

The drug transporter-metabolism alliance: uncovering and defining the interplay.

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The drug transporter-metabolism alliance: uncovering and defining the interplay.

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type

label

The drug transporter-metabolism alliance: uncovering and defining the interplay.

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The drug transporter-metabolism alliance: uncovering and defining the interplay.

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prefLabel

The drug transporter-metabolism alliance: uncovering and defining the interplay.

@en

The drug transporter-metabolism alliance: uncovering and defining the interplay.

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Molecular Pharmaceutics

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The drug transporter-metabolism alliance: uncovering and defining the interplay.

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Leslie Z Benet

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P2860

Cloning and functional expression of a human liver organic cation transporter

CYP3A gene expression in human gut epithelium

The superfamily of organic anion transporting polypeptides.

The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity.

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Active secretion and enterocytic drug metabolism barriers to drug absorption.

Clearance concepts in pharmacokinetics.

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein.

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system.

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

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