A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.
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ApoE promotes the proteolytic degradation of AbetaA preclinical assessment of neural stem cells as delivery vehicles for anti-amyloid therapeuticsNeuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer diseaseNeuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's diseaseImplications of protein structure instability: from physiological to pathological secondary structure.Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic miceCandidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agentsImproved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase.Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies.HFE gene variants, iron, and lipids: a novel connection in Alzheimer's diseaseAmyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearanceBeneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice.ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function.The role of apolipoprotein E in Alzheimer's disease.Neprilysin-2 is an important β-amyloid degrading enzyme.Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model.Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assayIntroducing Human APOE into Aβ Transgenic Mouse Models.Evidence of a role for lactadherin in Alzheimer's diseaseLipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease.Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies.Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease.Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40.Novel strategies for Alzheimer's disease treatment.Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities.Abeta aggregation and possible implications in Alzheimer's disease pathogenesisFollowing activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration.Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficitsInhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.Diet and age interactions with regards to cholesterol regulation and brain pathogenesis.Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease.Alzheimer's Disease Risk Genes and Lipid Regulators.Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein.Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice.Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4.Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy.Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.Induction of apoptotic change in the rat hippocampus caused by ferric nitrilotriacetate.Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: the Hisayama Study.
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P2860
A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 13 September 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
A nontransgenic mouse model sh ...... tein E in the amyloid cascade.
@en
A nontransgenic mouse model shows inducible amyloid-beta
@nl
type
label
A nontransgenic mouse model sh ...... tein E in the amyloid cascade.
@en
A nontransgenic mouse model shows inducible amyloid-beta
@nl
prefLabel
A nontransgenic mouse model sh ...... tein E in the amyloid cascade.
@en
A nontransgenic mouse model shows inducible amyloid-beta
@nl
P2860
P356
P1476
A nontransgenic mouse model sh ...... tein E in the amyloid cascade.
@en
P2093
Daniel M Michaelson
Iftach Dolev
P2860
P304
13909-13914
P356
10.1073/PNAS.0404458101
P407
P577
2004-09-13T00:00:00Z