Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential
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Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's DiseaseNovel NMDA receptor modulators: an updateRecent progress in understanding subtype specific regulation of NMDA receptors by G Protein Coupled Receptors (GPCRs)X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptorDynamics and allosteric potential of the AMPA receptor N-terminal domainSubunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptorsComparative Dynamics of NMDA- and AMPA-Glutamate Receptor N-Terminal DomainsNMDA receptor structures reveal subunit arrangement and pore architecture.Glutamate receptor ion channels: structure, regulation, and functionDevelopment of NMDAR antagonists with reduced neurotoxic side effects: a study on GK11Unprecedented therapeutic potential with a combination of A2A/NR2B receptor antagonists as observed in the 6-OHDA lesioned rat model of Parkinson's diseaseMapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptorPotentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptorsZinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunitNR2B Antagonist CP-101,606 Abolishes Pitch-Mediated Deviance Detection in Awake Rats.Allosteric modulation of glycine receptors.MultiBac complexomics.{EXPRESS] Endocytosis of GluN2B-containing NMDA receptors mediates NMDA-induced excitotoxicity.Sniffer patch laser uncaging response (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearanceIntracranial self-stimulation to evaluate abuse potential of drugs.Case report: anaesthetic management of radical gastrectomy for gastric cancer associated with anti-N-methyl-D-aspartate receptor encephalitis.Metal and complementary molecular bioimaging in Alzheimer's disease.Metal imaging in neurodegenerative diseases.What is the new target inhibiting the progression of Alzheimer's diseaseA series of structurally novel heterotricyclic alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor-selective antagonists.Life extension factor klotho enhances cognition.The NMDA receptor as a target for cognitive enhancementControl of assembly and function of glutamate receptors by the amino-terminal domain.GluN2B protein deficits in the left, but not the right, hippocampus in schizophrenia.Interaction between Analgesic Effect of Nano and Conventional size of Zinc Oxide and Opioidergic System Activity in Animal Model of Acute PainPotentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.N-methyl-D-aspartate receptor subunit composition in the rat trigeminal principal nucleus remains constant during postnatal development and following neonatal denervationTransient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide-gated channelsNeurological effects of inorganic arsenic exposure: altered cysteine/glutamate transport, NMDA expression and spatial memory impairment.Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons.mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivoInhibition of the polyamine system counteracts β-amyloid peptide-induced memory impairment in mice: involvement of extrasynaptic NMDA receptors.Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's diseaseNew advances in NMDA receptor pharmacology.
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P2860
Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Allosteric modulators of NR2B- ...... isms and therapeutic potential
@en
Allosteric modulators of NR2B- ...... sms and therapeutic potential.
@nl
type
label
Allosteric modulators of NR2B- ...... isms and therapeutic potential
@en
Allosteric modulators of NR2B- ...... sms and therapeutic potential.
@nl
prefLabel
Allosteric modulators of NR2B- ...... isms and therapeutic potential
@en
Allosteric modulators of NR2B- ...... sms and therapeutic potential.
@nl
P2093
P2860
P1476
Allosteric modulators of NR2B- ...... isms and therapeutic potential
@en
P2093
James N C Kew
Laetitia Mony
Martin J Gunthorpe
Pierre Paoletti
P2860
P304
P356
10.1111/J.1476-5381.2009.00304.X
P407
P577
2009-07-08T00:00:00Z