The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development
about
The emerging role and targetability of the TCA cycle in cancer metabolism.Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.Inappropriate costimulation and aberrant DNA methylation as therapeutic targets in angioimmunoblastic T-cell lymphoma.Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas.Angioimmunoblastic T-cell lymphoma: more than a disease of T follicular helper cells.Loss of 5-hydroxymethylcytosine is a frequent event in Peripheral T cell lymphomas.
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The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 December 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The IDH2 R172K mutation associ ...... d impacts lymphoid development
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The IDH2 R172K mutation associ ...... impacts lymphoid development.
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type
label
The IDH2 R172K mutation associ ...... d impacts lymphoid development
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The IDH2 R172K mutation associ ...... impacts lymphoid development.
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The IDH2 R172K mutation associ ...... d impacts lymphoid development
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The IDH2 R172K mutation associ ...... impacts lymphoid development.
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P2093
P2860
P50
P356
P1476
The IDH2 R172K mutation associ ...... d impacts lymphoid development
@en
P2093
Andrew Wakeham
Aurélie Dupuy
Bryan E Snow
Erica R Tobin
Katherine Yen
Nadine Martin
Rob A Cairns
Rohini Narayanaswamy
Romain Pelletier
Satoshi Inoue
P2860
P304
15084-15089
P356
10.1073/PNAS.1617929114
P407
P50
P577
2016-12-12T00:00:00Z