Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregation.
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Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domainCrystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutationsSelf-assembly and supramolecular organization of EMILINLateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alphaThe molecular defect in type IIB von Willebrand disease. Identification of four potential missense mutations within the putative GpIb binding domainMolecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequencesType IIB von Willebrand's disease: gene mutations and clinical presentation in nine families from Denmark, Germany and Sweden.Interaction of porcine von Willebrand factor with the platelet glycoproteins Ib and IIb/IIIa complex.Platelet activation and alpha granule secretion in type IIB von Willebrand's disease.Investigation of platelet function and platelet disorders using flow cytometry.Platelet aggregation induced by type IIb platelet von Willebrand factor.Type 2B von Willebrand disease with or without large multimers: A distinction of the two sides of the disorder is long overdueIIB von Willebrand's disease: pathogenetic and therapeutic studies.Type IIB von Willebrand's disease with probable autosomal recessive inheritance and presenting as thrombocytopenia in infancy.Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling.von Willebrand factor synthesized by endothelial cells from a patient with type IIB von Willebrand disease supports platelet adhesion normally but has an increased affinity for platelets.von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.Distinct abnormalities in the interaction of purified types IIA and IIB von Willebrand factor with the two platelet binding sites, glycoprotein complexes Ib-IX and IIb-IIIaMapping the N-glycome of human von Willebrand factor.Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE).von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia.Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex.Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptorsAnalysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression modelThe role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activationSrc family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.Functional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to plateletsMicrofluidic devices for studies of shear-dependent platelet adhesion.von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor.Interaction of the von Willebrand factor (vWF) with collagen. Localization of the primary collagen-binding site by analysis of recombinant vWF a domain polypeptides.Pathogenesis, clinical picture and treatment of von Willebrand's disease.The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation.A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3.14-3-3 zeta mediates integrin-induced activation of Cdc42 and Rac. Platelet glycoprotein Ib-IX regulates integrin-induced signaling by sequestering 14-3-3 zeta.Factor VIII/von Willebrand factor. Structure and function.
P2860
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P2860
Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregation.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Interaction of purified type I ...... lex and initiates aggregation.
@en
Interaction of purified type I ...... lex and initiates aggregation.
@nl
type
label
Interaction of purified type I ...... lex and initiates aggregation.
@en
Interaction of purified type I ...... lex and initiates aggregation.
@nl
prefLabel
Interaction of purified type I ...... lex and initiates aggregation.
@en
Interaction of purified type I ...... lex and initiates aggregation.
@nl
P2093
P2860
P356
P1476
Interaction of purified type I ...... lex and initiates aggregation.
@en
P2093
A Girolami
L De Marco
T S Zimmerman
Z M Ruggeri
P2860
P304
P356
10.1073/PNAS.82.21.7424
P407
P577
1985-11-01T00:00:00Z