Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
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Survivin monomer plays an essential role in apoptosis regulationHsp60 regulation of tumor cell apoptosisSurvivin 2alpha: a novel Survivin splice variant expressed in human malignanciesSurvivin: a unique target for tumor therapyLocalization and upregulation of survivin in cancer health disparities: a clinical perspectiveSurvivin - biology and potential as a therapeutic target in oncologySurvivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasionTumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategiesSurvivin as a target for new anticancer interventionsHeat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateSmac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathwaySurvivin splice variants regulate the balance between proliferation and cell deathA novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activityAn intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI)The effect of antineoplastic drugs in a male spontaneous mammary tumor modelSurvivin modulates microtubule dynamics and nucleation throughout the cell cycle.Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cellsATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagyCarboxyfullerenes localize within mitochondria and prevent the UVB-induced intrinsic apoptotic pathway.Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma.Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrityThe role of survivin in podocyte injury induced by puromycin aminonucleosideMolecular alterations in key-regulator genes among patients with T4 breast carcinoma.Forced expression of survivin-2B abrogates mitotic cells and induces mitochondria-dependent apoptosis by blockade of tubulin polymerization and modulation of Bcl-2, Bax, and survivin.C-jun inhibits mammary apoptosis in vivo.Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progression.Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension.Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)Prostate cancer regulatory networksLoss of cytoplasmic CDK1 predicts poor survival in human lung cancer and confers chemotherapeutic resistanceEssential role of the small GTPase Ran in postnatal pancreatic islet development.Dynamic changes to survivin subcellular localization are initiated by DNA damagePreclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancerA cell-permeable dominant-negative survivin protein induces apoptosis and sensitizes prostate cancer cells to TNF-α therapy.YM155 induces EGFR suppression in pancreatic cancer cells.Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemiaTargeting nucleocytoplasmic transport in cancer therapyGap junction enhancer increases efficacy of cisplatin to attenuate mammary tumor growthNucleo-cytoplasmic transport as a therapeutic target of cancerHuman ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP.
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Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
@en
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
@nl
type
label
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
@en
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
@nl
prefLabel
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
@en
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
@nl
P2093
P2860
P356
P1476
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
@en
P2093
Dario C Altieri
Elena Beltrami
Janet Plescia
Takehiko Dohi
P2860
P304
P356
10.1172/JCI200422222
P407
P577
2004-10-01T00:00:00Z