c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. - Test2 - elhamkhani - TriplyDB

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.

http://www.wikidata.org/entity/Q37585215

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Oxidative stress responses and NRF2 in human leukaemia Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance.The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1.The molecular mechanics of mixed lineage leukemia.Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemia SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice.Dual transcriptome sequencing reveals resistance of TLR4 ligand-activated bone marrow-derived macrophages to inflammation mediated by the BET inhibitor JQ1.Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer.Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts New Approaches to Target T-ALL.Epigenetics in T-cell acute lymphoblastic leukemia.Genomics in acute lymphoblastic leukaemia: insights and treatment implications.Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes.Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: emerging preclinical and clinical evidence.Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond.Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia.BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.Microenvironmental cues for T-cell acute lymphoblastic leukemia development.Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia.Bromodomain and extraterminal protein inhibitors in pediatrics: A review of the literature.Genetic Basis of Acute Lymphoblastic Leukemia.A Novel Epi-drug Therapy Based on the Suppression of BET Family Epigenetic Readers.The Varied Roles of Notch in Cancer.CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells.A positive feedback loop involving the Wnt/β-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphoma The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models.Therapeutic targeting of c-Myc in T-cell acute lymphoblastic leukemia, T-ALL RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia.Targeting oncoproteins for degradation by small molecules in myeloid leukemia.Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological cancers.

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c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.

http://www.wikidata.org/entity/Q37585215

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on 06 January 2014

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

c-Myc inhibition prevents leuk ...... failure pediatric T-ALL cells.

@en

c-Myc inhibition prevents leuk ...... failure pediatric T-ALL cells.

@nl

type

label

c-Myc inhibition prevents leuk ...... failure pediatric T-ALL cells.

@en

c-Myc inhibition prevents leuk ...... failure pediatric T-ALL cells.

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prefLabel

c-Myc inhibition prevents leuk ...... failure pediatric T-ALL cells.

@en

c-Myc inhibition prevents leuk ...... failure pediatric T-ALL cells.

@nl

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BLOOD-2013-08-522698

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c-Myc inhibition prevents leuk ...... failure pediatric T-ALL cells.

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A Thomas Look

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Dale L Greiner

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James E Bradner

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Jessica Tesell

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Jun Qi

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Justine E Roderick

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Leonard D Shultz

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Lewis B Silverman

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Marian H Harris

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Michael A Brehm

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P2860

The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

Selective inhibition of BET bromodomains

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

Expression profiling reveals off-target gene regulation by RNAi

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

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1040-1050

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scholarly article

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10.1182/BLOOD-2013-08-522698

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7

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Alejandro Gutierrez

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2014-01-06T00:00:00Z

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259606801

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