Epitope determinants of a chimpanzee Fab antibody that efficiently cross-neutralizes dengue type 1 and type 2 viruses map to inside and in close proximity to fusion loop of the dengue type 2 virus envelope glycoprotein.

Epitope determinants of a chimpanzee Fab antibody that efficiently cross-neutralizes dengue type 1 and type 2 viruses map to inside and in close proximity to fusion loop of the dengue type 2 virus envelope glycoprotein.

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Q37596501

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Possible future monoclonal antibody (mAb)-based therapy against arbovirus infections Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody Cryptic Properties of a Cluster of Dominant Flavivirus Cross-Reactive Antigenic Sites Crystal Structure of West Nile Virus Envelope Glycoprotein Reveals Viral Surface Epitopes Antibody Recognition and Neutralization Determinants on Domains I and II of West Nile Virus Envelope Protein Induction of Epitope-Specific Neutralizing Antibodies against West Nile Virus Epitope Determinants of a Chimpanzee Dengue Virus Type 4 (DENV-4)-Neutralizing Antibody and Protection against DENV-4 Challenge in Mice and Rhesus Monkeys by Passively Transferred Humanized Antibody Type- and Subcomplex-Specific Neutralizing Antibodies against Domain III of Dengue Virus Type 2 Envelope Protein Recognize Adjacent Epitopes Monoclonal Antibodies That Bind to Common Epitopes on the Dengue Virus Type 2 Nonstructural-1 and Envelope Glycoproteins Display Weak Neutralizing Activity and Differentiated Responses to Virulent Strains: Implications for Pathogenesis and Vaccines Humanized Monoclonal Antibodies Derived from Chimpanzee Fabs Protect against Japanese Encephalitis Virus In Vitro and In Vivo Antibodies to Envelope Glycoprotein of Dengue Virus during the Natural Course of Infection Are Predominantly Cross-Reactive and Recognize Epitopes Containing Highly Conserved Residues at the Fusion Loop of Domain II Closing the door on flaviviruses: Entry as a target for antiviral drug design The structural immunology of antibody protection against West Nile virus Humoral Immune Responses of Dengue Fever Patients Using Epitope-Specific Serotype-2 Virus-Like Particle Antigens Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development Impact of Quaternary Organization on the Antigenic Structure of the Tick-Borne Encephalitis Virus Envelope Glycoprotein E Dengue virus neutralization is modulated by IgG antibody subclass and Fcγ receptor subtype The Development of Therapeutic Antibodies That Neutralize Homologous and Heterologous Genotypes of Dengue Virus Type 1 Structure of the St. Louis Encephalitis Virus Postfusion Envelope Trimer Identification of a New Broadly Cross-reactive Epitope within Domain III of the Duck Tembusu Virus E Protein Pathogenesis and Inhibition of Flaviviruses from a Carbohydrate Perspective Chimpanzee Fab fragments and a derived humanized immunoglobulin G1 antibody that efficiently cross-neutralize dengue type 1 and type 2 viruses.A broadly flavivirus cross-neutralizing monoclonal antibody that recognizes a novel epitope within the fusion loop of E protein.Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2.Epitope reactions can be gauged by relative antibody discriminating specificity (RADS) values supported by deletion, substitution and cysteine bridge formation analyses: potential uses in pathogenesis studies.Development of a humanized antibody with high therapeutic potential against dengue virus type 2 Mechanistic study of broadly neutralizing human monoclonal antibodies against dengue virus that target the fusion loop.Variation of the specificity of the human antibody responses after tick-borne encephalitis virus infection and vaccination.Dissection of antibody specificities induced by yellow fever vaccination A Highly Sensitive Diagnostic System for Detecting Dengue Viruses Using the Interaction between a Sulfated Sugar Chain and a Virion.Characterization of a Novel Dengue Serotype 4 Virus-Specific Neutralizing Epitope on the Envelope Protein Domain III.The molecular basis of antibody-mediated neutralization of West Nile virus.Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody.DENV-2 subunit proteins fused to CR2 receptor-binding domain (P28)-induces specific and neutralizing antibodies to the Dengue virus in mice.Receptors and routes of dengue virus entry into the host cells.Generation and characterization of a monoclonal antibody that cross-reacts with the envelope protein from the four dengue virus serotypes.Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement.Intrahost Selection Pressures Drive Rapid Dengue Virus Microevolution in Acute Human Infections.

P2860

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P2860

Epitope determinants of a chimpanzee Fab antibody that efficiently cross-neutralizes dengue type 1 and type 2 viruses map to inside and in close proximity to fusion loop of the dengue type 2 virus envelope glycoprotein.

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http://www.wikidata.org/entity/Q37596501

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article científic

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artigo científico

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bilimsel makale

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scientific article published on December 2004

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