Herpes simplex virus type 1 glycoprotein K and the UL20 protein are interdependent for intracellular trafficking and trans-Golgi network localization
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Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopmentTegument Assembly and Secondary Envelopment of AlphaherpesvirusesHerpes simplex virus 1 protein UL37 interacts with viral glycoprotein gK and membrane protein UL20 and functions in cytoplasmic virion envelopment.The herpes simplex virus type 1 UL20 protein and the amino terminus of glycoprotein K (gK) physically interact with gB.The amino terminus of herpes simplex virus 1 glycoprotein K is required for virion entry via the paired immunoglobulin-like type-2 receptor alphaA single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.Site-specific proteolytic cleavage of the amino terminus of herpes simplex virus glycoprotein K on virion particles inhibits virus entry.The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopmentThe antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation.Functional and physical interactions of the herpes simplex virus type 1 UL20 membrane protein with glycoprotein KHerpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice.Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responsesThe amino terminus of herpes simplex virus type 1 glycoprotein K (gK) modulates gB-mediated virus-induced cell fusion and virion egress.Herpes simplex virus type 1 gK is required for gB-mediated virus-induced cell fusion, while neither gB and gK nor gB and UL20p function redundantly in virion de-envelopmentVaricella-Zoster Virus Glycoproteins: Entry, Replication, and Pathogenesis.Functional hierarchy of herpes simplex virus 1 viral glycoproteins in cytoplasmic virion envelopment and egressDeletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons.The herpes simplex virus type 1 (HSV-1) glycoprotein K(gK) is essential for viral corneal spread and neuroinvasiveness.Contribution of endocytic motifs in the cytoplasmic tail of herpes simplex virus type 1 glycoprotein B to virus replication and cell-cell fusion.Cysteines and N-glycosylation Sites Conserved Among all Alphaherpesviruses Regulate Membrane Fusion in Herpes Simplex Virus Type 1 Infection.Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K.UL20 protein functions precede and are required for the UL11 functions of herpes simplex virus type 1 cytoplasmic virion envelopment.The equine herpesvirus 1 UL20 product interacts with glycoprotein K and promotes egress of mature particles.Focal adhesion kinase plays a pivotal role in herpes simplex virus entry.HSV-1 gM and the gK/pUL20 complex are important for the localization of gD and gH/L to viral assembly sites.Herpes simplex virus 1 envelopment follows two diverse pathways.Herpes simplex virus type 1 capsids transit by the trans-Golgi network, where viral glycoproteins accumulate independently of capsid egress.Herpes simplex virus 1 glycoprotein M and the membrane-associated protein UL11 are required for virus-induced cell fusion and efficient virus entryFunctional hierarchy of herpes simplex virus type-1 membrane proteins in corneal infection and virus transmission to ganglionic neurons.The herpes simplex virus type 1 glycoprotein D (gD) cytoplasmic terminus and full-length gE are not essential and do not function in a redundant manner for cytoplasmic virion envelopment and egress.Protein Composition of the Bovine Herpesvirus 1.1 Virion.The absence of DHHC3 affects primary and latent HSV-1 infection.The Amino-terminus of HSV-1 Glycoprotein K (gK) is Required for gB Binding to Akt, Release of Intracellular Calcium and Fusion of the Viral Envelope with Plasma Membranes.A Tyrosine-Based Trafficking Motif of the Tegument Protein pUL71 Is Crucial for Human Cytomegalovirus Secondary Envelopment.Experimental Dissection of the Lytic Replication Cycles of Herpes Simplex VirusesQualitative Differences in Capsidless L-Particles Released as a By-Product of Bovine Herpesvirus 1 and Herpes Simplex Virus 1 Infections
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P2860
Herpes simplex virus type 1 glycoprotein K and the UL20 protein are interdependent for intracellular trafficking and trans-Golgi network localization
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2004
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Herpes simplex virus type 1 gl ...... ans-Golgi network localization
@en
Herpes simplex virus type 1 gl ...... ns-Golgi network localization.
@nl
type
label
Herpes simplex virus type 1 gl ...... ans-Golgi network localization
@en
Herpes simplex virus type 1 gl ...... ns-Golgi network localization.
@nl
prefLabel
Herpes simplex virus type 1 gl ...... ans-Golgi network localization
@en
Herpes simplex virus type 1 gl ...... ns-Golgi network localization.
@nl
P2093
P2860
P1433
P1476
Herpes simplex virus type 1 gl ...... ans-Golgi network localization
@en
P2093
Jeffrey M Melancon
Konstantin G Kousoulas
Timothy P Foster
Trisha L Olivier
P2860
P304
13262-13277
P356
10.1128/JVI.78.23.13262-13277.2004
P407
P577
2004-12-01T00:00:00Z