mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development.
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Store-operated calcium entry and diabetic complicationsPDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascadeBrain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated TumorigenesisMTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1High glucose and diabetes enhanced store-operated Ca(2+) entry and increased expression of its signaling proteins in mesangial cells.Anti-proliferative Effects of Nucleotides on Gastric Cancer via a Novel P2Y6/SOCE/Ca2+/β-catenin Pathway.Enhanced Orai1 and STIM1 expression as well as store operated Ca2+ entry in therapy resistant ovary carcinoma cells.STIM1 accelerates cell senescence in a remodeled microenvironment but enhances the epithelial-to-mesenchymal transition in prostate cancerSTIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis.Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathwayStore-Operated Ca2+ Channels in Mesangial Cells Inhibit Matrix Protein Expression.Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development.Up-regulation of brain-expressed X-linked 2 is critical for hepatitis B virus X protein-induced hepatocellular carcinoma development.Negative regulation of Smad1 pathway and collagen IV expression by store-operated Ca2+ entry in glomerular mesangial cells.Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex.mTOR promotes pituitary tumor development through activation of PTTG1.
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mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 29 October 2012
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
mTORC1 enhancement of STIM1-me ...... lex-related tumor development.
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mTORC1 enhancement of STIM1-me ...... lex-related tumor development.
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type
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mTORC1 enhancement of STIM1-me ...... lex-related tumor development.
@en
mTORC1 enhancement of STIM1-me ...... lex-related tumor development.
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mTORC1 enhancement of STIM1-me ...... lex-related tumor development.
@en
mTORC1 enhancement of STIM1-me ...... lex-related tumor development.
@nl
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mTORC1 enhancement of STIM1-me ...... lex-related tumor development.
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C L Walker
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10.1038/ONC.2012.481
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2012-10-29T00:00:00Z