about
Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1.Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral responseExisting antivirals are effective against influenza viruses with genes from the 1918 pandemic virus.mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infectionGenetically engineered Newcastle disease virus for malignant melanoma therapySequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genesGenomic analysis of increased host immune and cell death responses induced by 1918 influenza virusStructure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I ActivationInfluenza virus NS1 protein counteracts PKR-mediated inhibition of replication.A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in miceA novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responsesEnhancement of Zika virus pathogenesis by preexisting antiflavivirus immunityH5N1, a wealth of knowledge to improve pandemic preparedness.The pause on Avian H5N1 influenza virus transmission research should be endedPlasmid-only rescue of influenza A virus vaccine candidates.Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenzaInfluenza virus still surprises.Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus.Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus.A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity.Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in miceWhat can we learn from reconstructing the extinct 1918 pandemic influenza virus?Evolution of the hemagglutinin protein of the new pandemic H1N1 influenza virus: maintaining optimal receptor binding by compensatory substitutions.The guinea pig as a transmission model for human influenza virusesOne-shot vaccination with an insect cell-derived low-dose influenza A H7 virus-like particle preparation protects mice against H7N9 challenge.Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination.Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets.Divergent H7 immunogens offer protection from H7N9 virus challenge.Lessons learned from reconstructing the 1918 influenza pandemic.Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.North American triple reassortant and Eurasian H1N1 swine influenza viruses do not readily reassort to generate a 2009 pandemic H1N1-like virus.Multiple anti-interferon actions of the influenza A virus NS1 proteinThe origin of the PB1 segment of swine influenza A virus subtype H1N2 determines viral pathogenicity in miceTurkey versus guinea pig red blood cells: hemagglutination differences alter hemagglutination inhibition responses against influenza A/H1N1.The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses.Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangementsInduction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells.Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPaseImmunologic characterization of a rhesus macaque H1N1 challenge model for candidate influenza virus vaccine assessment.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Adolfo García-Sastre
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Adolfo García-Sastre
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Adolfo García-Sastre
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Adolfo García-Sastre
@nl
Adolfo García-Sastre
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type
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Adolfo García-Sastre
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Adolfo García-Sastre
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Adolfo García-Sastre
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Adolfo García-Sastre
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Adolfo García-Sastre
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prefLabel
Adolfo García-Sastre
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Adolfo García-Sastre
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Adolfo García-Sastre
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Adolfo García-Sastre
@nl
Adolfo García-Sastre
@sl
P106
P1153
7006948562
P21
P31
P496
0000-0002-6551-1827