about
Structural model of the hUbA1-UbcH10 quaternary complex: in silico and experimental analysis of the protein-protein interactions between E1, E2 and ubiquitin8-methyl-2'-deoxyguanosine incorporation into parallel DNA quadruplex structuresMiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastomaMicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastomaStructural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4Circular dichroism and thermal melting differentiation of Hoechst 33258 binding to the curved (A(4)T(4)) and straight (T(4)A(4)) DNA sequences.Unusual monomolecular DNA quadruplex structures using bunch-oligonucleotides.Synthesis and characterization of monomolecular DNA G-quadruplexes formed by tetra-end-linked oligonucleotides.1H NMR studies of the 5-(hydroxymethyl)-2'-deoxyuridine containing TF1 binding site.Backbone modified TBA analogues endowed with antiproliferative activity.Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.Strand directionality affects cation binding and movement within tetramolecular G-quadruplexes.Transferrin-conjugated SNALPs encapsulating 2'-O-methylated miR-34a for the treatment of multiple myeloma.Oligonucleotide delivery in cancer therapy.Synthesis, structural studies and biological properties of new TBA analogues containing an acyclic nucleotide.Exploring the binding of d(GGGT)4 to the HIV-1 integrase: An approach to investigate G-quadruplex aptamer/target protein interactions.Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity.A straightforward modification in the thrombin binding aptamer improving the stability, affinity to thrombin and nuclease resistance.5-Hydroxymethyl-2'-deoxyuridine residues in the thrombin binding aptamer: investigating anticoagulant activity by making a tiny chemical modification.Expanding the potential of G-quadruplex structures: formation of a heterochiral TBA analogue.Interrelations of secondary structure stability and DNA-binding affinity in the bacteriophage SPO1-encoded type II DNA-binding protein TF1.Biophysical properties of quadruple helices of modified human telomeric DNA.On the connection between inherent DNA flexure and preferred binding of hydroxymethyluracil-containing DNA by the type II DNA-binding protein TF1.Localized DNA flexibility contributes to target site selection by DNA-bending proteins.The Introduction of Inversion of Polarity Sites in DNA G-Quadruplex Structures: Effects and Perspectives.Monomolecular G-quadruplex structures with inversion of polarity sites: new topologies and potentiality.MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines.Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer.Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands.Improved thrombin binding aptamer analogues containing inversion of polarity sites: structural effects of extra-residues at the ends.Effects of abasic sites on structural, thermodynamic and kinetic properties of quadruplex structures.The insertion of two 8-methyl-2'-deoxyguanosine residues in tetramolecular quadruplex structures: trying to orientate the strands.A novel pyrimidine tetrad contributing to stabilize tetramolecular G-quadruplex structures.The oxidative damage to the human telomere: effects of 5-hydroxymethyl-2'-deoxyuridine on telomeric G-quadruplex structures.Synthesis of quadruplex-forming tetra-end-linked oligonucleotides: effects of the linker size on quadruplex topology and stability.2'-Deoxy-8-(propyn-1-yl)adenosine-containing oligonucleotides: effects on stability of duplex and quadruplex structures.Synthesis of 5-methylamino-2'-deoxyuridine derivatives.The abasic site lesions in the human telomeric sequence d[TA(G(3)T(2)A)(3)G(3)]: a thermodynamic point of view.Effect of a modified thymine on the structure and stability of [d(TGGGT)]4 quadruplex.1H-NMR study of the quadruplex [d(TGGGT)]4 containing a modified thymine.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Aldo Galeone
@ast
Aldo Galeone
@en
Aldo Galeone
@es
Aldo Galeone
@nl
Aldo Galeone
@sl
type
label
Aldo Galeone
@ast
Aldo Galeone
@en
Aldo Galeone
@es
Aldo Galeone
@nl
Aldo Galeone
@sl
prefLabel
Aldo Galeone
@ast
Aldo Galeone
@en
Aldo Galeone
@es
Aldo Galeone
@nl
Aldo Galeone
@sl
P106
P1153
7004138534
P21
P31
P496
0000-0001-8805-6348