Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim.
about
Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure−activity relationshipsStructure-activity relationships of Bacillus cereus and Bacillus anthracis dihydrofolate reductase: toward the identification of new potent drug leadsSynthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate ReductaseCrystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and SelectivityX-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor designInhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis.Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracisIdentification of novel potential antibiotics against Staphylococcus using structure-based drug screening targeting dihydrofolate reductaseEvaluation of the metS and murB loci for antibiotic discovery using targeted antisense RNA expression analysis in Bacillus anthracis.In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis.Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthase.Potential biological targets of Bacillus anthracis in anti-infective approaches against the threat of bioterrorism.Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges.Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.
P2860
Q24594645-79EB0BFD-240F-4FE8-8598-E680E2C191C3Q24673580-9DF6531D-21C6-44E4-9701-34F2B48A7375Q27652892-EE7C028C-CF61-43AE-BC2D-9872E434A35AQ27654731-65C94F55-86D4-43B9-9377-A40BF89B1337Q27654896-55905C1D-A740-477F-8BB0-2AE5BACADE5BQ27663178-A762FFD8-85F4-4141-89BF-74E229B636D6Q33594516-857197EF-86D9-4371-9545-7420746C158BQ33935343-74CE94E9-6C0C-418F-B223-DB9BE76BBD45Q34781493-C9091729-1628-4C7D-85BF-F5F3BDA2A931Q35100832-EA3B39A6-D216-4967-B682-D959120EA1F9Q35759041-1A6AA082-ECC4-4049-837C-EC3872BFD2D6Q36313194-6F45F4C8-086C-48FD-A46B-F6D6EB81D66AQ36744550-19AEF8DE-4D24-4AC5-B10C-70E905FAC288Q36901955-9385C73B-8320-43AA-B526-1CAA2E1A6F67Q38026606-28ED4ED9-7C1D-49C7-8025-5BCB929FA044Q38792855-FA717DBC-BA9F-4382-963D-DFD6FEB72C16
P2860
Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Functional cloning of Bacillus ...... al resistance to trimethoprim.
@en
Functional cloning of Bacillus ...... al resistance to trimethoprim.
@nl
type
label
Functional cloning of Bacillus ...... al resistance to trimethoprim.
@en
Functional cloning of Bacillus ...... al resistance to trimethoprim.
@nl
prefLabel
Functional cloning of Bacillus ...... al resistance to trimethoprim.
@en
Functional cloning of Bacillus ...... al resistance to trimethoprim.
@nl
P2093
P2860
P1476
Functional cloning of Bacillus ...... al resistance to trimethoprim.
@en
P2093
Esther W Barrow
Philip C Bourne
William W Barrow
P2860
P304
P356
10.1128/AAC.48.12.4643-4649.2004
P407
P577
2004-12-01T00:00:00Z