The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
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Changes in Regenerative Capacity through LifespanMediation of organismal aging and somatic proteostasis by the germlineAltered lipid metabolism in the aging kidney identified by three layered omic analysisSQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body DementiaProgress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013.PABPN1-Dependent mRNA Processing Induces Muscle Wasting.Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging.The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span.Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence.Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegansRoyal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease.Evidence for the hallmarks of human aging in replicatively aging yeast.The role of protein clearance mechanisms in organismal ageing and age-related diseases.PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro ModelEmbryonic stem cells: a novel paradigm to study proteostasis?The Proteasome Inhibition Model of Parkinson's Disease.Clinical pharmacology, creating current and future success in drug development.Proteasome expression and activity in cancer and cancer stem cells.Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasisImportance of adiponectin activity in the pathogenesis of Alzheimer's disease.Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus.Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome.Formal Models of Biological Systems.Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.Proteasome and Organs Ischemia-Reperfusion Injury.Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells.MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4BDCAF13 E3 Ligase in Osteosarcoma Cells.Aging-Associated Decline of Epidermal PSMD8 Contributes to Impaired Skin Function.Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and Immunogenicity.Abnormal Epigenetic Regulation of Immune System during Aging.Long-lived rodents reveal signatures of positive selection in genes associated with lifespan.Accurate translation is important for longevity.Proteasome Activity Is Influenced by the HECT_2 Protein Ipa1 in Budding YeastDynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons.Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimer's Disease.
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The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2014
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
@en
The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
@nl
type
label
The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
@en
The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
@nl
prefLabel
The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
@en
The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
@nl
P2860
P1433
P1476
The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
@en
P2093
Isabel Saez
P2860
P356
10.2174/138920291501140306113344
P577
2014-02-01T00:00:00Z