The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.
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RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitroOsteoimmunology: interactions of the bone and immune systemIdentification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiationSignaling Pathways in Osteoclast DifferentiationOsteoimmunology and the influence of pro-inflammatory cytokines on osteoclastsFeedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone LossRegulation of NFATc1 in Osteoclast DifferentiationLoss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCsFibrillin-1 directly regulates osteoclast formation and function by a dual mechanismImmune complexes regulate bone metabolism through FcRγ signallingArctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathwaysA Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint InflammationIntegrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsTULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast functionSignal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorptionLIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)Tyrosine kinase inhibitors for the treatment of rheumatoid arthritisSH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells.Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFATCytoskeletal dysfunction dominates in DAP12-deficient osteoclastsIdentification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery.Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus.Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure.Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency.Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiationBlimp1-mediated repression of negative regulators is required for osteoclast differentiation.Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor.The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase.DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment.Impact of dietary aromatic amino acids on osteoclastic activityOsteoclast motility: putting the brakes on bone resorption.Getting Syk: spleen tyrosine kinase as a therapeutic target.Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal boneSimvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis.
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The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 08 April 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The immunomodulatory adapter p ...... rough the Syk tyrosine kinase.
@en
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain
@nl
type
label
The immunomodulatory adapter p ...... rough the Syk tyrosine kinase.
@en
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain
@nl
prefLabel
The immunomodulatory adapter p ...... rough the Syk tyrosine kinase.
@en
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain
@nl
P2093
P2860
P356
P1476
The immunomodulatory adapter p ...... rough the Syk tyrosine kinase.
@en
P2093
Andrew Burghardt
Clifford A Lowell
Jessica A G Van Ziffle
Lewis L Lanier
Mary Beth Humphrey
Mary C Nakamura
Sharmila Majumdar
Steven C Spusta
Yongmei Hu
P2860
P304
P356
10.1073/PNAS.0401602101
P407
P577
2004-04-08T00:00:00Z