Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.
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Redox regulation of proteasome function.Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells.Increased expression of the tight junction protein TJP1/ZO-1 is associated with upregulation of TAZ-TEAD activity and an adult tissue stem cell signature in carfilzomib-resistant multiple myeloma cells and high-risk multiple myeloma patients.Nrf2: not "lost in translation".Nrf2-Mediated Metabolic Reprogramming in Cancer.Molecular responses to therapeutic proteasome inhibitors in multiple myeloma patients are donor-, cell type- and drug-dependent.
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Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 September 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Noncanonical SQSTM1/p62-Nrf2 p ...... d translational reprogramming.
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Noncanonical SQSTM1/p62-Nrf2 p ...... d translational reprogramming.
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Noncanonical SQSTM1/p62-Nrf2 p ...... d translational reprogramming.
@en
Noncanonical SQSTM1/p62-Nrf2 p ...... d translational reprogramming.
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Noncanonical SQSTM1/p62-Nrf2 p ...... d translational reprogramming.
@en
Noncanonical SQSTM1/p62-Nrf2 p ...... d translational reprogramming.
@nl
P2093
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Noncanonical SQSTM1/p62-Nrf2 p ...... d translational reprogramming.
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Jeffrey W Marsal
Robert G Hawley
Teresa S Hawley
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P304
66360-66385
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10.18632/ONCOTARGET.11960
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P577
2016-09-10T00:00:00Z