Single-molecule spectroscopy reveals polymer effects of disordered proteins in crowded environments.
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Insights into Coupled Folding and Binding Mechanisms from Kinetic StudiesPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Shedding light on protein folding, structural and functional dynamics by single molecule studiesRelating sequence encoded information to form and function of intrinsically disordered proteinsWhat macromolecular crowding can do to a proteinThe contribution of intrinsically disordered regions to protein function, cellular complexity, and human diseaseTransient binding accounts for apparent violation of the generalized Stokes-Einstein relation in crowded protein solutions.Macromolecular and Small Molecular Crowding Have Similar Effects on α-Synuclein Structure.Predicting Molecular Crowding Effects in Ion-RNA InteractionsAssemblages: functional units formed by cellular phase separationProbing protein disorder and complexity at single-molecule resolution.The lifestyle switch protein Bd0108 of Bdellovibrio bacteriovorus is an intrinsically disordered proteinTargeting intrinsically disordered proteins in rational drug discovery.The Differential Response of Proteins to Macromolecular CrowdingConformation and Dynamics of the Troponin I C-Terminal Domain: Combining Single-Molecule and Computational Approaches for a Disordered Protein Region.Tick receptor for outer surface protein A from Ixodes ricinus - the first intrinsically disordered protein involved in vector-microbe recognition.Protein Composition Determines the Effect of Crowding on the Properties of Disordered Proteins.Folding propensity of intrinsically disordered proteins by osmotic stress.Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation.Dynamic footprint of sequestration in the molecular fluctuations of osteopontinProtein folding, binding, and droplet formation in cell-like conditions.Model studies of the effects of intracellular crowding on nucleic acid interactions.Microorganisms maintain crowding homeostasis.To be disordered or not to be disordered: is that still a question for proteins in the cell?Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods.Probing the Action of Chemical Denaturant on an Intrinsically Disordered Protein by Simulation and Experiment.Crowding in Cellular Environments at an Atomistic Level from Computer Simulations.Excluded-volume effects in living cells.Single-molecule fluorescence-based analysis of protein conformation, interaction, and oligomerization in cellular systems.Topology of polymer chains under nanoscale confinement.Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure.Soft interactions and volume exclusion by polymeric crowders can stabilize or destabilize transient structure in disordered proteins depending on polymer concentration.Quarterly intrinsic disorder digest (April-May-June, 2014).Combining Diffusion NMR and Small-Angle Neutron Scattering Enables Precise Measurements of Polymer Chain Compression in a Crowded Environment.Solvent effects in the helix-coil transition model can explain the unusual biophysics of intrinsically disordered proteins.Persistence-length renormalization of polymers in a crowded environment of hard disks.Design and Properties of Genetically Encoded Probes for Sensing Macromolecular Crowding.Structure Versus Stochasticity-The Role of Molecular Crowding and Intrinsic Disorder in Membrane Fission.Intrinsically Disordered Protein Exhibits Both Compaction and Expansion under Macromolecular Crowding.Self-interaction of NPM1 modulates multiple mechanisms of liquid-liquid phase separation.
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Single-molecule spectroscopy reveals polymer effects of disordered proteins in crowded environments.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Single-molecule spectroscopy r ...... teins in crowded environments.
@en
Single-molecule spectroscopy r ...... teins in crowded environments.
@nl
type
label
Single-molecule spectroscopy r ...... teins in crowded environments.
@en
Single-molecule spectroscopy r ...... teins in crowded environments.
@nl
prefLabel
Single-molecule spectroscopy r ...... teins in crowded environments.
@en
Single-molecule spectroscopy r ...... teins in crowded environments.
@nl
P2093
P2860
P356
P1476
Single-molecule spectroscopy r ...... teins in crowded environments.
@en
P2093
Andrea Soranno
Benjamin Schuler
Daniel Nettels
Franziska Zosel
Hagen Hofmann
Iwo Koenig
Madeleine B Borgia
P2860
P304
P356
10.1073/PNAS.1322611111
P407
P577
2014-03-17T00:00:00Z