The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules.
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Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences.Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LLCytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells.Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids.Unfolding Kinetics of the Human Telomere i-Motif Under a 10 pN Force Imposed by the α-Hemolysin Nanopore Identify Transient Folded-State Lifetimes at Physiological pH.Long-Lived Excited-State Dynamics of i-Motif Structures Probed by Time-Resolved Infrared Spectroscopy.Porphyrin Bound to i-Motifs: Intercalation versus External Groove Binding.GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1Stabilization of i-motif structures by 2'-β-fluorination of DNA.The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif.The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective TargetProperties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.Identification of multiple genomic DNA sequences which form i-motif structures at neutral pHHnRNP-L promotes prostate cancer progression by enhancing cell cycling and inhibiting apoptosis.The structure of an endogenous Drosophila centromere reveals the prevalence of tandemly repeated sequences able to form i-motifsOdorant Sensory Input Modulates DNA Secondary Structure Formation and Heterogeneous Ribonucleoprotein Recruitment on the Tyrosine Hydroxylase and Glutamic Acid Decarboxylase 1 Promoters in the Olfactory Bulb.The importance of loop length on the stability of i-motif structures.Preferential targeting of i-motifs and G-quadruplexes by small molecules.Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression.2'-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA.Evaluation of stability of DNA i-motifs in the nuclei of living mammalian cells.BmILF and i-motif structure are involved in transcriptional regulation of BmPOUM2 in Bombyx mori.The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription.Detection of protonated non-Watson-Crick base pairs using electrospray ionization mass spectrometry.Topological impact of noncanonical DNA structures on Klenow fragment of DNA polymerase.From direct to indirect lithium targets: a comprehensive review of omics data.Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids.Probing Synergistic Effects of DNA Methylation and 2'-β-Fluorination on i-Motif Stability.i-Motif of cytosine-rich human telomere DNA fragments containing natural base lesions.Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks.i-Clamp phenoxazine for the fine tuning of DNA i-motif stability.i-Motifs are more stable than G-quadruplexes in a hydrated ionic liquid.Probing structural changes of self assembled i-motif DNA.DNA quadruplexes as molecular scaffolds for controlled assembly of fluorogens with aggregation-induced emission.Tuning the pH Response of i-Motif DNA OligonucleotidesModulation of the stability of i-motif structures using an acyclic threoninol cytidine derivativeFundamental aspects of the nucleic acid i-motif structures
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The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The transcriptional complex be ...... modulated by small molecules.
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The transcriptional complex be ...... modulated by small molecules.
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type
label
The transcriptional complex be ...... modulated by small molecules.
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The transcriptional complex be ...... modulated by small molecules.
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prefLabel
The transcriptional complex be ...... modulated by small molecules.
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The transcriptional complex be ...... modulated by small molecules.
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P2093
P2860
P356
P1476
The transcriptional complex be ...... modulated by small molecules.
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P2093
Hyun-Jin Kang
Laurence H Hurley
Samantha Kendrick
Sidney M Hecht
P2860
P304
P356
10.1021/JA4109352
P407
P577
2014-03-07T00:00:00Z