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Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell deathPerforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.Secretory pathway of cellulase: a mini-reviewInfection history determines the differentiation state of human CD8+ T cellsGranule Associated Serine Proteases of Hematopoietic Cells - An Analysis of Their Appearance and Diversification during Vertebrate Evolution.Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells.Pediatric Primitive Neuroectodermal Tumors of the Central Nervous System Differentially Express Granzyme InhibitorsOropharyngeal squamous cell carcinomas differentially express granzyme inhibitors.Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes.Cell death-independent functions of granzymes: hit viruses where it hurts.Granzyme M: behind enemy lines.Blood and beyond: properties of circulating and tissue-resident human virus-specific αβ CD8(+) T cells.Granzyme K-deficient mice show no evidence of impaired antiviral immunity.Expression of intra- and extracellular granzymes in patients with typhoid fever.Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication.Granzymes A and K differentially potentiate LPS-induced cytokine response.Cleavage of Notch1 by granzyme B disables its transcriptional activity.A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells.All human granzymes target hnRNP K that is essential for tumor cell viability.A novel proinflammatory role for granzyme AGranzyme M cannot induce cell death via cleavage of mouse FADD.Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus.Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity.Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma.CD45+CD33lowCD11bdim myeloid-derived suppressor cells suppress CD8+ T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer.
P2860
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P2860
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on May 2010
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Orphan granzymes find a home.
@en
Orphan granzymes find a home.
@nl
type
label
Orphan granzymes find a home.
@en
Orphan granzymes find a home.
@nl
prefLabel
Orphan granzymes find a home.
@en
Orphan granzymes find a home.
@nl
P2860
P1476
Orphan granzymes find a home.
@en
P2093
J Alain Kummer
Niels Bovenschen
P2860
P304
P356
10.1111/J.0105-2896.2010.00889.X
P577
2010-05-01T00:00:00Z