The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities. - Test2 - elhamkhani - TriplyDB

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

http://www.wikidata.org/entity/Q37805340

about

Structure-Based Design of Covalent Siah Inhibitors Two high-resolution structures of the human E3 ubiquitin ligase Siah1 Mechanisms of synergism between antagonists of growth hormone-releasing hormone and antagonists of luteinizing hormone-releasing hormone in shrinking experimental benign prostatic hyperplasia.Recent progress in targeting cancer.Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells.The "Sharp" blade against HIF-mediated metastasis.Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling.c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer.SIAH proteins: critical roles in leukemogenesis.Regulators and effectors of Siah ubiquitin ligases.Maintaining and reprogramming genomic androgen receptor activity in prostate cancer.Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.WWP2 ubiquitin ligase and its isoforms: new biological insight and promising disease targets.

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P2860

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

http://www.wikidata.org/entity/Q37805340

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on September 2010

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

@en

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

@nl

type

label

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

@en

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

@nl

prefLabel

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

@en

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

@nl

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The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.

@en

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Jianfei Qi

http://www.w3.org/2001/XMLSchema#string

Maurizio Pellecchia

http://www.w3.org/2001/XMLSchema#string

Ze'ev A Ronai

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Creative Commons Attribution 2.5 Unported

P2860

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth

Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors

Neuroendocrine differentiation in prostate cancer

Kinetics of neuroendocrine differentiation in an androgen-dependent human prostate xenograft model

Interleukin-6- and cyclic AMP-mediated signaling potentiates neuroendocrine differentiation of LNCaP prostate tumor cells.

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling

Cancer stem cells: mirage or reality?

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia

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379-385

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scholarly article

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10.18632/ONCOTARGET.171

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5

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1

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2010-09-01T00:00:00Z

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47636611

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21037926

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P921

nuclear protein

prostate cancer

neuroendocrine tumor

DNA-binding protein

transcription factor

tumor biomarkers

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2964873

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