about
Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the EndotheliumEndothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endotheliumPressor actions of arginine vasopressin in pithed Sprague-Dawley, Wistar-Kyoto and spontaneously hypertensive rats before and after treatment with nifedipine or pertussis toxinChloride removal and excitation-contraction coupling in guinea pig ileal smooth muscleMultiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arteriolesInhibition of field stimulation-evoked relaxations in rat oesophageal smooth muscle by the calcium antagonist PN 200-110Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscleTwenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity.Novel endothelium-derived relaxing factors. Identification of factors and cellular targets.Endothelium-derived hyperpolarizing factor: is there a novel chemical mediator?The endothelium: influencing vascular smooth muscle in many ways.NO and the vasculature: where does it come from and what does it do?NO/PGI2-independent vasorelaxation and the cytochrome P450 pathway in rabbit carotid artery.Cardiovascular effects of CPU-23, a novel L-type calcium channel blocker with a unique molecular structure.Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical arteryEndothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouseEndothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone.Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms.The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes.Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidantsPharmacological characterization of the postsynaptic alpha adrenoceptors in vascular smooth muscle from canine and rat mesenteric vascular beds.On the oxalate stimulation of ATP-dependent calcium accumulation by smooth muscle subcellular membranes.Nature of norepinephrine-sensitive Ca-pool in rabbit aortic smooth muscle: effect of pH.Chloride removal selectively inhibits phasic contractions of guinea pig ileal longitudinal smooth muscle.The early effects of elevated glucose on endothelial function as a target in the treatment of type 2 diabetes.A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries.Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1.Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways.A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS.The endothelium in compliance and resistance vessels.A nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist reverses endothelial dysfunction in diabetic (db/db-/-) mice.Challenges in the Biomedical Research Enterprise in the 21st century: Antecedents in the writings of David Triggle.An analysis of the action of lanthanum on aortic tissue from normotensive and spontaneously hypertensive rats.Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function.A review of changes in vascular smooth muscle functions in hypertension: isolated tissue versus in vivo studies.Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells.Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin.Vascular alpha-adrenoceptors: from the gene to the human.The future of pharmacology in Canada.
P50
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P50
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հետազոտող
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Chris R Triggle
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Chris R Triggle
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P106
P31
P496
0000-0001-5307-0537