about
Tuning cell cycle regulation with an iron key.N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.Targeting cancer by binding iron: Dissecting cellular signaling pathwaysThe Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling PathwaysThe novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.The TGF-beta, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer.Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.The medicinal chemistry of novel iron chelators for the treatment of cancer.The role of NDRG1 in the pathology and potential treatment of human cancers.Iron chelation: inhibition of key signaling pathways in the induction of the epithelial mesenchymal transition in pancreatic cancer and other tumors.Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition.The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1)Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling.Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization.Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.Metals and metastasis: Exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents.Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways.Investigating the spectrum of biological activity of ring-substituted salicylanilides and carbamoylphenylcarbamates.Iron chelation: deciphering novel molecular targets for cancer therapy. The tip of the iceberg of a web of iron-regulated molecules.Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones.The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets.The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism.Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).Making a case for albumin – a highly promising drug-delivery system.A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity.The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms.Targeting Iron in Cancer Cells: A New Strategy to Inhibit Metastatic ProgressionChelators to the Rescue: Different Horses for Different Courses!Overcoming tamoxifen resistance in oestrogen receptor-positive breast cancer using the novel thiosemicarbazone anti-cancer agent, DpC
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Zaklina Kovacevic
@ast
Zaklina Kovacevic
@en
Zaklina Kovacevic
@es
Zaklina Kovacevic
@nl
Zaklina Kovacevic
@sl
type
label
Zaklina Kovacevic
@ast
Zaklina Kovacevic
@en
Zaklina Kovacevic
@es
Zaklina Kovacevic
@nl
Zaklina Kovacevic
@sl
prefLabel
Zaklina Kovacevic
@ast
Zaklina Kovacevic
@en
Zaklina Kovacevic
@es
Zaklina Kovacevic
@nl
Zaklina Kovacevic
@sl
P106
P21
P31
P496
0000-0002-4742-4690