Structural and biophysical determinants of αβ T-cell antigen recognition.
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Identifying Individual T Cell Receptors of Optimal Avidity for Tumor AntigensMajor Histocompatibility Complex Class II Dextramers: New Tools for the Detection of antigen-Specific, CD4 T Cells in Basic and Clinical ResearchMore tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimersT-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen TargetingT-cell Receptor Specificity Maintained by Altered ThermodynamicsIncreased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking modeT-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex InteractionsMining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) Web-Server.Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategiesAntibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRsImproving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor.T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cellsSoluble T-cell receptors produced in human cells for targeted delivery.Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptideβ-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.Quantitative phosphoproteomic analysis reveals a role for serine and threonine kinases in the cytoskeletal reorganization in early T cell receptor activation in human primary T cells.Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.Cellular-level versus receptor-level response threshold hierarchies in T-cell activation.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.The versatility of the αβ T-cell antigen receptor.The molecular determinants of CD8 co-receptor function.Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.The unique surface molecules on intestinal intraepithelial lymphocytes: from tethering to recognizing.Understanding the complexity and malleability of T-cell recognition.The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.ImmTAC-redirected tumour cell killing induces and potentiates antigen cross-presentation by dendritic cells.Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms.Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope.Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor bindingAdvances in T-cell epitope engineering.Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides.Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response.
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Structural and biophysical determinants of αβ T-cell antigen recognition.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Structural and biophysical determinants of αβ T-cell antigen recognition.
@en
Structural and biophysical determinants of αβ T-cell antigen recognition.
@nl
type
label
Structural and biophysical determinants of αβ T-cell antigen recognition.
@en
Structural and biophysical determinants of αβ T-cell antigen recognition.
@nl
prefLabel
Structural and biophysical determinants of αβ T-cell antigen recognition.
@en
Structural and biophysical determinants of αβ T-cell antigen recognition.
@nl
P2860
P50
P1433
P1476
Structural and biophysical determinants of αβ T-cell antigen recognition.
@en
P2093
John S Bridgeman
P2860
P356
10.1111/J.1365-2567.2011.03515.X
P577
2012-01-01T00:00:00Z