Mass spectrometry based tools to investigate protein-ligand interactions for drug discovery.
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Protein-carbohydrate interactions studied by NMR: from molecular recognition to drug designPredicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug DesignMass spectrometry coupled experiments and protein structure modeling methods.Proteins with highly similar native folds can show vastly dissimilar folding behavior when desolvated.Desalting large protein complexes during native electrospray mass spectrometry by addition of amino acids to the working solution.Hydrogen-deuterium exchange mass spectrometry for determining protein structural changes in drug discovery.Mass spectrometric approaches to study protein structure and interactions in lyophilized powders.Interfacing low-energy SAW nebulization with Liquid Chromatography-Mass Spectrometry for the analysis of biological samples.Optimization of Electrospray Ionization by Statistical Design of Experiments and Response Surface Methodology: Protein-Ligand Equilibrium Dissociation Constant Determinations.The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.Applications of Biophysics in High-Throughput Screening Hit Validation.Probing structures of large protein complexes using zero-length cross-linking.Genetic screening reveals a link between Wnt signaling and antitubulin drugs.Mass spectrometry-based monitoring of millisecond protein-ligand binding dynamics using an automated microfluidic platformMass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24.Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates.Collidoscope: An Improved Tool for Computing Collisional Cross-Sections with the Trajectory Method.A suspension-cell biosensor for real-time determination of binding kinetics of protein-carbohydrate interactions on cancer cell surfaces.Predicting protein aggregation during storage in lyophilized solids using solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS)The use of ion mobility mass spectrometry to assist protein design: a case study on zinc finger fold versus coiled coil interactions.Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase.Investigation of dendriplexes by ion mobility-mass spectrometry.Photoaffinity casting of a coumarin flag for rapid identification of ligand-binding sites within protein.Native Mass Spectrometry from Common Buffers with Salts That Mimic the Extracellular Environment.The intrinsically disordered N-terminal arm of the brome mosaic virus coat protein specifically recognizes the RNA motif that directs the initiation of viral RNA replication.Dissociation kinetics of the streptavidin-biotin interaction measured using direct electrospray ionization mass spectrometry analysis.Combining Mass Spectrometry and X-Ray Crystallography for Analyzing Native-Like Membrane Protein Lipid Complexes.Tandem mass spectrometric analysis of novel peptide-modified gemini surfactants used as gene delivery vectors.Separation of glycosidic catiomers by TWIM-MS using CO2 as a drift gas.Allosteric modulation of protein-protein interactions by individual lipid binding events.Study on the Structural Effect of Maltoligosaccharides on Cytochrome c Complexes Stabilities by Native Mass Spectrometry.Mass spectrometry and NMR analysis of ligand binding by human liver fatty acid binding protein.ATP and autophosphorylation driven conformational changes of HipA kinase revealed by ion mobility and crosslinking mass spectrometry.The effect of a covalent and a noncovalent small-molecule inhibitor on the structure of Abg β-glucosidase in the gas-phase.Allostery revealed within lipid binding events to membrane proteins.Ion mobility coupled to native mass spectrometry as a relevant tool to investigate extremely small ligand-induced conformational changes.
P2860
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P2860
Mass spectrometry based tools to investigate protein-ligand interactions for drug discovery.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
Mass spectrometry based tools ...... teractions for drug discovery.
@en
type
label
Mass spectrometry based tools ...... teractions for drug discovery.
@en
prefLabel
Mass spectrometry based tools ...... teractions for drug discovery.
@en
P2093
P2860
P356
P1476
Mass spectrometry based tools ...... teractions for drug discovery.
@en
P2093
Kamila J Pacholarz
Rachel A Garlish
Richard J Taylor
P2860
P304
P356
10.1039/C2CS35035A
P577
2012-04-24T00:00:00Z