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TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stressPulmonary capillary hemangiomatosis: a focus on the EIF2AK4 mutation in onset and pathogenesisTargeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour developmentCantharidins induce ER stress and a terminal unfolded protein response in OSCC.C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4Glucose deprivation induces chemoresistance in colorectal cancer cells by increasing ATF4 expressionRole of Eukaryotic Initiation Factors during Cellular Stress and Cancer ProgressionMitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway.Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer.Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity.Translational regulator eIF2α in tumor.Endoplasmic reticulum stress: key promoter of rosacea pathogenesis.ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner.Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition.The Interconnections between Autophagy and Integrin-Mediated Cell Adhesion.biRte: Bayesian inference of context-specific regulator activities and transcriptional networks.Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein Response.Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma.Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation.The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomasBH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma.Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition.Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia.Up-Regulated ATF4 Expression Increases Cell Sensitivity to Apoptosis in Response to Radiation.DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance.Cross-talk between protein synthesis, energy metabolism and autophagy in cancer.Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma.Pathway-focused PCR array profiling of CAL-27 cell with over-expressed ZNF750.Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Targeting the ATF4 pathway in cancer therapy.
@en
type
label
Targeting the ATF4 pathway in cancer therapy.
@en
prefLabel
Targeting the ATF4 pathway in cancer therapy.
@en
P2860
P1476
Targeting the ATF4 pathway in cancer therapy.
@en
P2093
Dean C Singleton
P2860
P304
P356
10.1517/14728222.2012.728207
P407
P577
2012-09-26T00:00:00Z