The role of HOX genes in normal hematopoiesis and acute leukemia.
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Concise review: programming human pluripotent stem cells into bloodTracking context-specific transcription factors regulating hox activityMEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.Therapeutic Resistance in Acute Myeloid Leukemia: The Role of Non-Coding RNAsRegulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human DiseaseRole of HOXA9 in leukemia: dysregulation, cofactors and essential targetsEpigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis.Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino AmericansFlexible model-based clustering of mixed binary and continuous data: application to genetic regulation and cancer.A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specificationHigher HOPX expression is associated with distinct clinical and biological features and predicts poor prognosis in de novo acute myeloid leukemiaC/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesisAberrant RNA splicing and mutations in spliceosome complex in acute myeloid leukemia.Cytogenetic as an important tool for diagnosis and prognosis for patients with hypocellular primary myelodysplastic syndrome.Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes.Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: a microarray related study.Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in AML.Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations.The deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesisTargeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial SkeletonElucidation of the Molecular Interaction between miRNAs and the HOXA9 Gene, Involved in Acute Myeloid Leukemia, by the Assistance of Argonaute Protein through a Computational ApproachHOTAIR is upregulated in acute myeloid leukemia and that indicates a poor prognosis.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyondIdentifying Network Perturbation in Cancer.The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other MalignanciesCCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis.NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia.Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.Large-scale gene network analysis reveals the significance of extracellular matrix pathway and homeobox genes in acute myeloid leukemia: an introduction to the Pigengene package and its applications.Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2aElevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1Digging deep into "dirty" drugs - modulation of the methylation machinery.miR-199b, a novel tumor suppressor miRNA in acute myeloid leukemia with prognostic implicationsMedial HOXA genes demarcate haematopoietic stem cell fate during human development.Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia.CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseasesPotential pathological and functional links between long noncoding RNAs and hematopoiesis.Role of long non-coding RNAs in normal and malignant hematopoiesis.
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The role of HOX genes in normal hematopoiesis and acute leukemia.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
The role of HOX genes in normal hematopoiesis and acute leukemia.
@en
type
label
The role of HOX genes in normal hematopoiesis and acute leukemia.
@en
prefLabel
The role of HOX genes in normal hematopoiesis and acute leukemia.
@en
P2860
P356
P1433
P1476
The role of HOX genes in normal hematopoiesis and acute leukemia
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P2093
H S Pandha
R Pettengell
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P2888
P304
P356
10.1038/LEU.2012.356
P577
2012-12-05T00:00:00Z
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P6179
1022402035